Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Digitonin enhances the ef… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration.

Artikel i vetenskaplig tidskrift
Författare Per Lindnér
D Heath
S B Howell
Peter Naredi
Lars-Olof Hafström
Publicerad i Cancer chemotherapy and pharmacology
Volym 40
Nummer/häfte 5
Sidor 444-8
ISSN 0344-5704
Publiceringsår 1997
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
Sidor 444-8
Språk en
Länkar dx.doi.org/10.1007/s002800050684
Ämnesord Animals, Antineoplastic Agents, administration & dosage, pharmacology, Carboplatin, administration & dosage, pharmacology, Detergents, pharmacology, Digitonin, pharmacology, Female, Hepatic Artery, Infusions, Intra-Arterial, Liver Neoplasms, Experimental, blood supply, drug therapy, Male, Organ Size, Rats, Rats, Inbred Strains
Ämneskategorier Cancer och onkologi

Sammanfattning

Platinum-containing drugs enter the cell slowly and have a poor tissue penetration. Increasing the permeability of the cell membrane might increase the intracellular drug concentration. Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro. The aim of this study was to determine whether digitonin could increase the efficacy of carboplatin (CBDCA) in vivo. In LH rats, a hepatoma was implanted in the liver. At 7 days after implantation, digitonin (or saline in the control group) was infused via the hepatic artery and, 10 min later, CBDCA was injected. Biopsies from the tumour and liver parenchyma were obtained after 1 h. The concentration of platinum measured in the liver tumours was higher in the digitonin group than in the control groups. In the liver parenchyma the concentrations were of the same magnitude. Measured with the 133Xe-clearance technique, digitonin did not alter the tumour blood flow. Digitonin enhanced the tumour-growth-retarding effect of CBDCA given intra-arterially at 5 mg/kg but not at 25 mg/kg. No increase in toxicity was observed for digitonin given together with CBDCA at 5 mg/kg. Systemic administration of CBDCA was not influenced by digitonin. These findings demonstrate that pretreatment with digitonin increases the tumour uptake of CBDCA and potentiates the cytotoxic effect of CBDCA.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?