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S-phase fraction related to prognosis in localised prostate cancer. No specific significance of chromosome 7 gain or deletion of 7q31.1.

Artikel i vetenskaplig tidskrift
Författare Lennart Åström
Anna Weimarck
Frank Aldenborg
Ulla Delle
Charles Hanson
I Verbiene
Anna Danielsson
Jan Hammarsten
Istvan Köpf
Publicerad i International journal of cancer. Journal international du cancer
Volym 79
Nummer/häfte 6
Sidor 553-9
ISSN 0020-7136
Publiceringsår 1998
Publicerad vid Institutionen för särskilda specialiteter, Avdelningen för onkologi
Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi
Sidor 553-9
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adenocarcinoma, genetics, mortality, Aged, Chromosome Aberrations, Chromosome Deletion, Chromosomes, Human, Pair 7, Flow Cytometry, Humans, In Situ Hybridization, Fluorescence, Male, Ploidies, Prognosis, Prostatic Neoplasms, genetics, mortality, Retrospective Studies, S Phase
Ämneskategorier Cancer och onkologi

Sammanfattning

A flow-cytometric (FCM) and fluorescence in situ hybridization (FISH) study was performed in 153 patients with clinically localised prostate cancer (PC) to evaluate retrospectively the prognostic significance of DNA ploidy, S-phase fraction (SPF) and chromosome 7 copy number. Deletions in 7q31.1 were analysed in a subset of 26 tumours. The mean follow-up time was 6 years (range 4-16 years). Twelve cases of benign prostatic hyperplasia (BPH) were studied as a control. Chromosome 7 enumeration and deletion studies were conducted using the alpha-satellite D7Z1 probe and a cosmid probe specific for the marker D7S522 on 7q31.1. Higher SPF was associated with shorter overall survival and shorter time to local progression and metastasis. Near diploid (DNA index 1.05-1.20) cases had a lower frequency of metastases and lower Gleason scores than aneuploid cases. Increased absolute chromosome 7 copy number (centromere count) was associated with higher Gleason score, higher SPF and shorter local progression-free and prostate cancer survival. Absolute chromosome 7 copy number was concordant with FCM DNA ploidy in the majority (75%) of cases. Relative gain or loss of chromosome 7 (centromere counts compared to ploidy) was infrequent, and no correlation was found with clinical parameters. Deletions in 7q31.1 were infrequent. Our results indicate that in localised PC (i) SPF is a prognostic factor, (ii) absolute chromosome 7 copy number is concordant with the ploidy status of the tumour (relative gain or loss of chromosome 7 is infrequent and has no independent prognostic value) and (iii) the frequency of deletions in 7q31.1 is low and not correlated with clinical outcome.

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