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The relevance of somatostatin receptors in thyroid neoplasia.

Artikel i övriga tidskrifter
Författare Håkan Ahlman
Lars-Eric Tisell
Bo Wängberg
M Fjälling
Eva Forssell-Aronsson
Lars Kölby
Ola Nilsson
Publicerad i The Yale journal of biology and medicine
Volym 70
Nummer/häfte 5-6
Sidor 523-33
ISSN 0044-0086
Publiceringsår 1997
Publicerad vid Institutionen för särskilda specialiteter, Avdelningen för radiofysik
Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
Sidor 523-33
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adenoma, Oxyphilic, radionuclide imaging, Adult, Aged, Blotting, Northern, Carcinoma, Medullary, Carcinoma, Papillary, radionuclide imaging, Female, Humans, Indium Radioisotopes, analysis, blood, diagnostic use, Lymphatic Metastasis, diagnosis, Male, Octreotide, diagnostic use, Receptors, Somatostatin, analysis, genetics, Thyroid Neoplasms, radionuclide imaging, secretion
Ämneskategorier Radiofysik, Gastroenterologi, Cancer och onkologi

Sammanfattning

111In-octreotide scintigraphy in patients with persistent medullary thyroid carcinoma (MTC) visualized tumors in about half of the surgically explored sites. Tumor visualization correlated with rapid tumor growth and large tumor volume as judged from calcitonin levels. The 111In concentration ratio between tumor (T) and blood (B) in surgically excised lymph node metastases of MTC showed a large variation, with low values for microscopic and high values for macroscopic metastases in individual patients. Three cases of MTC, Hürthle cell adenoma and papillary thyroid cancer are reported with preoperative scintigraphy, T/B ratios and Northern analyses of the surgical biopsies. Visualization of tumors was possible in the absence of sstr2 (the high affinity receptor for octreotide) with the exception of microscopic tumor growth. T/B values in the patient with Hürthle cell adenoma were similar to those found in the contralateral thyroid lobe with goitre. The relatively high uptake of 111In in benign thyroid conditions probably limits the use of octreotide scintigraphy in the diagnosis of primary tumors. The technique has certain advantages over radioiodine scintigraphy after the surgical treatment of thyroid tumors: no need for withdrawal of thyroxin substitution; a possibility to diagnose metastases of tumors that do not concentrate radioiodine (MTC, Hürthle cell cancer); and complementary information about metastatic sites of non-medullary thyroid cancer (papillary and follicular tumors).

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