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Nitric oxide in the control of submandibular gland function in the anaesthetized ferret.

Artikel i vetenskaplig tidskrift
Författare Gunnar Tobin
A V Edwards
S R Bloom
Jörgen Ekström
Publicerad i Experimental physiology
Volym 82
Nummer/häfte 5
Sidor 825-36
ISSN 0958-0670
Publiceringsår 1997
Publicerad vid Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi
Sidor 825-36
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Autonomic Agents, pharmacology, Blood Vessels, physiology, Electric Stimulation, Enzyme Inhibitors, pharmacology, Ferrets, Male, NG-Nitroarginine Methyl Ester, pharmacology, Nitric Oxide, physiology, Parasympathetic Nervous System, physiology, Saliva, secretion, Submandibular Gland, blood supply, physiology, secretion, Vasoactive Intestinal Peptide, metabolism
Ämneskategorier Farmakologi

Sammanfattning

Stimulation of parasympathetic innervation of the submandibular gland (2 or 20 Hz continuously or 20 Hz for 1 s at 10 s intervals), in the ferret, produced secretion of fluid and protein and a fall in vascular resistance. The responses following the administration of N omega-nitro-L-arginine methyl ester (L-NAME; 2 mmol kg-1 i.a.) to block the synthesis of nitric oxide (NO) were reduced, and the persisting responses were abolished (at 2 Hz continuously and 20 Hz intermittently) or further reduced (at 20 Hz continuously) by the additional administration of atropine. The output of vasoactive intestinal peptide (VIP) from the gland was not affected. Neither the secretory nor the vascular response to intra-arterial infusions of acetylcholine (1.25 nmol kg-1) was affected by L-NAME, whereas the vascular responses to both VIP (10 pmol kg-1) and pituitary adenylate cyclase-activating peptide (1-38) (PACAP) (0.5 pmol kg-1) were reduced thereby. Neither peptide evoked a fluid secretion per se. However, when infused during parasympathetic stimulation of saliva secretion, VIP increased both flow rate and the output of protein. These effects of VIP were abolished by L-NAME. The experiments were performed in the presence of sodium nitroprusside at doses (4-8 nmol min-1 kg-1 i.v.) aimed to counterbalance the systemic effects of L-NAME. The results show that, in the ferret, parasympathetic nerve activity increases submandibular blood flow, and elicits the flow of saliva and output of protein by mechanisms that involve in situ generation of NO, upon which the effects of VIP and PACAP but not acetylcholine are largely dependent.

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