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Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia.

Artikel i vetenskaplig tidskrift
Författare Henrik Hagberg
Peter Andersson
Ingemar Kjellmer
Klara Thiringer
Magnus Thordstein
Publicerad i Neuroscience letters
Volym 78
Nummer/häfte 3
Sidor 311-7
ISSN 0304-3940
Publiceringsår 1987
Publicerad vid Institutionen för pediatrik
Fysiologiska institutionen
Sidor 311-7
Språk en
Länkar dx.doi.org/10.1016/0304-3940(87)903...
Ämnesord Amino Acids, metabolism, Animals, Aspartic Acid, metabolism, Asphyxia, metabolism, Brain Ischemia, metabolism, Cerebrovascular Circulation, Evoked Potentials, Somatosensory, Fetus, metabolism, Glutamates, metabolism, Glutamic Acid, Hypoxia, Brain, metabolism, Sheep, Taurine, metabolism, Telencephalon, metabolism, physiopathology, gamma-Aminobutyric Acid, metabolism
Ämneskategorier Medicinska grundvetenskaper

Sammanfattning

Extracellular levels of excitatory and inhibitory amino acids were measured in the cortex and striatum of asphyxiated fetal lambs. The fetus was exteriorized from the anesthetized ewe and dialysis probes were placed in the parietal cortex and caudate nucleus. Cerebral blood flow was measured with Xe-clearance. Cortical somatosensory-evoked potentials and electroencephalogram (EEG) were continuously recorded. Asphyxia was induced by clamping the umbilical cord or by graded compression of the maternal aorta. Asphyxia accompanied by elevated cerebral blood flow resulted in a moderate rise in extracellular amino acid levels. During extreme asphyxia, i.e. abolished evoked potentials and reduced cerebral blood flow, marked extracellular elevations of glutamate (3- to 11-fold), aspartate (3- to 7-fold), gamma-aminobutyric acid (GABA) (3- to 5-fold) and taurine (3- to 18-fold) occurred, the higher values representing striatum. Excessive levels of excitatory amino acids may exert injurious effects on immature neurons during such hypoxic-ischemic states.

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