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Expression of glycolipid blood group antigens in single human kidneys: change in antigen expression of rejected ABO incompatible kidney grafts.

Artikel i vetenskaplig tidskrift
Författare A Ulfvin
A E Bäcker
H Clausen
S Hakomori
Lennart Rydberg
B E Samuelsson
Michael Breimer
Publicerad i Kidney international
Volym 44
Nummer/häfte 6
Sidor 1289-97
ISSN 0085-2538
Publiceringsår 1993
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
Sidor 1289-97
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord ABO Blood-Group System, immunology, Autoradiography, Blood Group Antigens, immunology, Blood Group Incompatibility, Chromatography, Thin Layer, Glycolipids, metabolism, Graft Rejection, immunology, Humans, Immunologic Techniques, Isoantigens, immunology, Kidney, metabolism, Lewis Blood-Group System, immunology, Staining and Labeling
Ämneskategorier Klinisk medicin

Sammanfattning

Total neutral glycolipid fractions were separated into molecular species on thin-layer chromatography plates and detected by immunostaining with monoclonal anti-blood group antibodies. Blood group A antigens based on type 1, 2, 3 and 4 carbohydrate core saccharides were present in kidneys of A1 and A1B individuals. Blood group A2 individuals expressed only small amounts of A antigen compared to A1 individuals especially of the type 3 and 4 compounds. Kidneys from non-secretor individuals contained less A antigen compared to secretor individuals, and in both groups a variation in the antigen expression between single individuals was noted. Blood group A type 2 and 3 (which is an extension of A type 2) antigens were present both as basic 6 and 9 sugar structures as well as extended saccharide chains migrating in the 8 to 11 sugar interval. In contrast, the type 1 chain based A and Lewis antigens were only present as their basic 5 to 7 sugar chains, and no elongated structures were found. Four cases of A2 kidneys initially transplanted into O recipients and removed after 5, 12, 21 days and 4 years, respectively, were also analyzed. Two of these kidneys, originating from the same donor, showed a difference in A antigen expression. The kidney functioning for four years (lost due to chronic rejection) completely lacked X antigen with five sugar residues (present in all other individuals) and contained a large amount of A antigens.(ABSTRACT TRUNCATED AT 250 WORDS)

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