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Advanced laryngeal cancer T3-T4 in Sweden: a retrospective study 1986-1990. Survival and locoregional control related to treatment.

Artikel i vetenskaplig tidskrift
Författare Caterina Finizia
A Geterud
E Holmberg
J Lindström
J Lundgren
R Kuylenstierna
R Rylander
A Biörklund
R Rydell
L Andréason
Claes Mercke
Publicerad i Acta oto-laryngologica
Volym 116
Nummer/häfte 6
Sidor 906-12
ISSN 0001-6489
Publiceringsår 1996
Publicerad vid Institutionen för särskilda specialiteter, Avdelningen för öron, näs- och halssjukdomar
Sidor 906-12
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Carcinoma, mortality, radiotherapy, surgery, Combined Modality Therapy, Female, Humans, Laryngeal Neoplasms, mortality, radiotherapy, surgery, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Survival Rate, Sweden, epidemiology
Ämneskategorier Cancer och onkologi, Klinisk medicin

Sammanfattning

Different treatment modalities for advanced laryngeal cancer are much discussed in the literature. One-hundred-and-sixty patients with T3-4, N0-3, M0-1 laryngeal cancer diagnosed in Sweden between 1986 and 1990 were retrospectively analysed. One hundred (65 T3: 35 T4) received radical radiotherapy with salvage surgery (RRSS) in case of residual or recurrent disease. Thirty-eight (11T3: 27 T4) patients received surgery with or without radiotherapy (S +/- RT). Twenty-two patients received no treatment. After a median follow up of 4.4 years, the estimated 5-year actuarial corrected survival and 3-year locoregional control were 59% and 44% for T3 RRSS and 47% and 54% for T3 S +/- RT. No significant difference between the different treatment modalities was found. The 5-year corrected survival rate and the locoregional control at 3 years between T4-RRSS (32%; 26%) and T4-S + RT (58%; 68%) groups were significantly different (p < 0.05 and p < 0.01). This might suggest that surgery with or without radiotherapy still has its place as a treatment modality for patients with advanced T4 laryngeal carcinoma.

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