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Respiratory and arousal responses to hypoxia in apnoeic infants reinvestigated.

Artikel i vetenskaplig tidskrift
Författare J Milerad
T Hertzberg
Göran Wennergren
H Lagercrantz
Publicerad i European journal of pediatrics
Volym 148
Nummer/häfte 6
Sidor 565-70
ISSN 0340-6199
Publiceringsår 1989
Publicerad vid Institutionen för pediatrik
Sidor 565-70
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Arousal, physiology, Blood Gas Monitoring, Transcutaneous, Female, Humans, Hypoxia, blood, physiopathology, Infant, Infant, Newborn, Male, Respiration, Sleep Apnea Syndromes, blood, physiopathology
Ämneskategorier Pediatrik, Fysiologi

Sammanfattning

Respiratory and arousal responses to mild hypoxia (15% oxygen in nitrogen) were recorded in 18 healthy infants and 33 infants who had sustained severe sleep related apnoeic events (ALTE). Respiratory movements and transcutaneous gas pressures (tcPO2 and tcPCO2) were continuously monitored during the 10 min test. The changes in tcPCO2 in relation to the decrease in tcPO2 were used as an index of the ventilatory and metabolic responses to hypoxia. We found that the response of apnoeic infants was within the range of the controls although the distribution of the individual response slopes was shifted towards the lower end of the range. Arousal was observed in 33% of apnoeic infants and 32% of the controls. Regular periodic breathing occurred in 42% of apnoeic infants compared to 28% of controls. In contrast to the controls, periodic breathing in apnoeic infants was not associated with a drop in tcPCO2 to below baseline levels. Apnoeic infants also alternated between regular and periodic breathing during the test. These findings are suggestive of a weak feed back control of breathing but do not support former views of a deficient hypoxic response in infants with ALTE.

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