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Leukotriene B4 and C4 generation by blood leukocytes after ex vivo stimulation by Ca-ionophore and opsonized zymosan in children with atopic dermatitis.

Artikel i vetenskaplig tidskrift
Författare T Shimizu
Sigurdur Kristjánsson
Göran Wennergren
Inga-Lisa Strannegård
Birgitta Strandvik
Publicerad i Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Volym 5
Nummer/häfte 2
Sidor 95-9
ISSN 0905-6157
Publiceringsår 1994
Publicerad vid Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 95-9
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adolescent, Calcimycin, pharmacology, Child, Child, Preschool, Dermatitis, Atopic, blood, Eosinophils, drug effects, physiology, Female, Humans, Leukocyte Count, Leukocytes, drug effects, metabolism, Leukotriene B4, biosynthesis, Leukotriene C4, biosynthesis, Male, Zymosan, pharmacology
Ämneskategorier Farmakologi, Pediatrik

Sammanfattning

The ex vivo release of leukotrienes B4 (LTB4) and C4 (LTC4) from the leukocytes of children with atopic dermatitis (AD) was evaluated after stimulation with Ca-ionophore and opsonized zymosan and compared with that of control children of similar ages. The blood eosinophil counts and total serum IgE levels in AD children were significantly higher than those in control children. The production of LTC4, but not LTB4, was significantly higher in AD children than in control children. There was a significant correlation between the relative blood eosinophil count and LTC4 generation after stimulation with both Ca-ionophore and opsonized zymosan in all subjects. Calculations of the amount of LTC4 produced per eosinophilic cell showed that there was no significant difference between cells from AD children and control children in terms of their ability to produce LTC4. These findings suggest that the enhanced LTC4 generation is due to increased numbers of eosinophils rather than to enhanced releasability of these cells.

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