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Expression of platelet-derived growth factor after intrastriatal ibotenic acid injury.

Artikel i vetenskaplig tidskrift
Författare M Sjöborg
K Pietz
A Ahgren
N Yamada
O Lindvall
Keiko Funa
P Odin
Publicerad i Experimental brain research
Volym 119
Nummer/häfte 2
Sidor 245-50
ISSN 0014-4819
Publiceringsår 1998
Publicerad vid Institutionen för anatomi och cellbiologi
Sidor 245-50
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Corpus Striatum, drug effects, metabolism, physiology, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Female, Huntington Disease, physiopathology, Ibotenic Acid, pharmacology, Immunohistochemistry, Kinetics, Platelet-Derived Growth Factor, genetics, metabolism, Polymerase Chain Reaction, RNA, Messenger, metabolism, Rats, Rats, Sprague-Dawley, Transcription, Genetic
Ämneskategorier Medicinska grundvetenskaper

Sammanfattning

The expression of platelet-derived growth factor (PDGF) was studied in a rat model of Huntington's disease, produced by unilateral intrastriatal ibotenic acid injections. The most pronounced effect registered was that the number of PDGF-immunoreactive cells increased in the lesioned area up to 10 weeks after the surgery. Double immunofluorescence staining indicated that the PDGF-positive cells were astrocytes. The increased PDGF immunoreactivity was associated with only minor changes in total PDGF mRNA and PDGF protein levels in the lesioned area. Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated a slight increase in PDGF mRNA after ibotenic acid lesion, but this was not reflected in an increase in PDGF A- and B-chain protein concentration as measured with ELISA. After sham operation an increase in PDGF protein concentration was seen, while the number of PDGF-immunoreactive cells was unchanged. The accumulation of PDGF in the astrocytes might reflect the role of PDGF in a repair process in neurodegenerative processes.

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