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Vigabatrin visual toxicity: evolution and dose dependence.

Artikel i vetenskaplig tidskrift
Författare K Malmgren
E Ben-Menachem
Lars Frisén
Publicerad i Epilepsia
Volym 42
Nummer/häfte 5
Sidor 609-15
ISSN 0013-9580
Publiceringsår 2001
Publicerad vid Institutionen för klinisk neurovetenskap, Sektionen för oftalmologi
Sidor 609-15
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Anticonvulsants, administration & dosage, adverse effects, therapeutic use, Dose-Response Relationship, Drug, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Retina, physiopathology, Vigabatrin, administration & dosage, adverse effects, therapeutic use, Vision Disorders, chemically induced, diagnosis, physiopathology, Visual Field Tests, methods, statistics & numerical data, Visual Fields, drug effects
Ämneskategorier Oftalmologi, Neurologi

Sammanfattning

To investigate the prevalence and prognosis of visual field defects (VFDs) in epilepsy patients with and without vigabatrin (VGB) treatment; to investigate the possible relationship between VFDs and cumulative VGB dose, and to characterise the evolution of VFDs.A cohort of 155 presurgical candidates who had undergone full-field Goldmann perimetry (GP) was studied, 99 (64%) of whom had been treated with VGB. All GPs were reevaluated in 1998 by one experienced examiner, blinded to medication. Duration of treatment and total VGB dose were related to perimetric results.Twenty-five (16%) of the 155 patients had VFDs: Nineteen (19%) of the 99 VGB-treated patients, and six (11%) of the 56 patients unexposed to VGB. VGB-treated patients with VFDs had been treated significantly longer than those without VFDs. Cumulative VGB dose could be calculated for 84 patients. The prevalence of VFDs increased significantly with increasing total VGB-dose, from 4% in the 51 patients who had been exposed to

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