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Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency.

Artikel i vetenskaplig tidskrift
Författare Gudmundur Johannsson
Thord Rosén
Ingvar Bosaeus
Lars Sjöström
Bengt-Åke Bengtsson
Publicerad i The Journal of clinical endocrinology and metabolism
Volym 81
Nummer/häfte 8
Sidor 2865-73
ISSN 0021-972X
Publiceringsår 1996
Publicerad vid Institutionen för invärtesmedicin
Sidor 2865-73
Språk en
Länkar dx.doi.org/10.1210/jcem.81.8.876884...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Absorptiometry, Photon, Adult, Aged, Blood, metabolism, Bone Density, drug effects, Bone Remodeling, drug effects, Bone and Bones, drug effects, pathology, Female, Growth Hormone, deficiency, therapeutic use, Humans, Hypopituitarism, metabolism, pathology, Male, Middle Aged, Sex Characteristics, Time Factors
Ämneskategorier Endokrinologi

Sammanfattning

The main purpose of this trial was to determine the effects of 2 yr of GH treatment on bone mineral density (BMD) and bone metabolism in patients with adult-onset GH deficiency. Forty-four patients (24 men and 20 women; aged 23-66 yr) participated in a 2-yr open treatment trial with recombinant human GH. BMD was assessed with dual energy x-ray absorptiometry, and serum concentrations of osteocalcin, carboxy-terminal propeptide of type I procollagen (PICP), and carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) were measured. After 2 yr of GH treatment, the BMD increased in the lumbar spine L2-L4 by 3.8% [95% confidence interval (CI), 2.1-5.5], in the femoral neck by 4.1% (CI, 2.1-6.1) in the femoral trochanter by 5.6% (CI, 3.8-7.4) and in Ward's triangle by 4.9% (CI, 2.2-7.6) compared with baseline. Patients with a z-score (difference in SD from the mean of age- and sex-matched subjects) below -1 SD responded with the most marked BMD increment. The serum concentrations of osteocalcin, PICP, and ICTP remained higher throughout the 2 yr of treatment. Women demonstrated a more marked increase in total body BMD and a less pronounced initial increment in osteocalcin, PICP, and ICTP than men. Two years of GH treatment induced a sustained increase in overall bone remodeling activity, which resulted in a net gain in BMD that was more marked in those subjects with a low pretreatment z-score.

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