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Relationship between mercury in kidney, blood, and urine in environmentally exposed individuals, and implications for biomonitoring

Artikel i vetenskaplig tidskrift
Författare Magnus Åkerström
Lars Barregård
T. Lundh
Gerd Sällsten
Publicerad i Toxicology and Applied Pharmacology
Volym 320
Sidor 17-25
ISSN 0041-008X
Publiceringsår 2017
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin
Sidor 17-25
Språk en
Länkar dx.doi.org/10.1016/j.taap.2017.02.0...
Ämnesord Mercury, Biomonitoring, Urine, Blood, Plasma, Kidney, DENTAL AMALGAM FILLINGS, OCCUPATIONAL EXPOSURE, EXCRETION, VAPOR, CADMIUM, POPULATION, WORKERS, ASSOCIATIONS, CLEARANCE, PROTEINS, Pharmacology & Pharmacy, Toxicology
Ämneskategorier Farmakologi och toxikologi

Sammanfattning

Background: Individuals without occupational exposure are exposed to mercury (Hg) from diet and dental amalgam. The kidney is a critical organ, but there is limited information regarding the relationship between Hg in kidney (K-Hg), urine (U-Hg), blood (B-Hg), and plasma (P-Hg). Objectives: The aim was to determine the relationship between K-Hg, U-Hg, B-Hg, and P-Hg among environmentally exposed individuals, estimate the biological half-time of K-Hg, and provide information useful for biomonitoring of Hg. Methods: Kidney cortex biopsies and urine and blood samples were collected from 109 living kidney donors. Total Hg concentrations were determined and the relationships between K-Hg, U-Hg, P-Hg, and B-Hg were investigated in regression models. The half-time of K-Hg was estimated from the elimination constant. Results: There were strong associations between K-Hg and all measures of U-Hg and P-Hg (r(p) = 0.65-0.84, p < 0.001), while the association with B-Hg was weaker (rp = 029, p = 0.002). Mean ratios between K-Hg (in mu g/g) and U-Hg/24h (in pg) and B-Hg (in mu g/L) were 0.22 and 0.19 respectively. Estimates of the biological half-time varied between 30 and 92 days, with significantly slower elimination in women. Adjusting overnight urine samples for dilution using urinary creatinine resulted in less bias in relation to K-Hg or U-Hg/24h, compared with other adjustment techniques. Conclusions: The relationship between K-Hg and U-Hg is approximately linear. K-Hg can be estimated using U-Hg and gender. Women have longer half-time of Hg in kidney compared to men. Adjusting overnight urine samples for creatinine concentration resulted in less bias. (C) 2017 Elsevier Inc. All rights reserved.

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