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Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland

Artikel i vetenskaplig tidskrift
Författare R. R. Seethala
Göran Stenman
Publicerad i Head & Neck Pathology
Volym 11
Nummer/häfte 1
Sidor 55-67
ISSN 1936-055X
Publiceringsår 2017
Publicerad vid Sahlgrenska Cancer Center
Sidor 55-67
Språk en
Länkar dx.doi.org//10.1007/s12105-017-0795...
Ämnesord World Health Organization, Salivary gland, Translocations, Molecular, Correlative, Neoplasia, analog secretory carcinoma, low-grade adenocarcinoma, sclerosing, polycystic adenosis, ex-pleomorphic adenoma, epithelial-myoepithelial, carcinoma, intercalated duct lesions, basal-cell adenoma, mucoepidermoid, carcinoma, cribriform adenocarcinoma, parotid-gland
Ämneskategorier Cancer och onkologi

Sammanfattning

The salivary gland section in the 4th edition of the World Health Organization classification of head and neck tumors features the description and inclusion of several entities, the most significant of which is represented by (mammary analogue) secretory carcinoma. This entity was extracted mainly from acinic cell carcinoma based on recapitulation of breast secretory carcinoma and a shared ETV6-NTRK3 gene fusion. Also new is the subsection of "Other epithelial lesions," for which key entities include sclerosing polycystic adenosis and intercalated duct hyperplasia. Many entities have been compressed into their broader categories given clinical and morphologic similarities, or transitioned to a different grouping as was the case with low-grade cribriform cystadenocarcinoma reclassified as intraductal carcinoma (with the applied qualifier of low-grade). Specific grade has been removed from the names of the salivary gland entities such as polymorphous adenocarcinoma, providing pathologists flexibility in assigning grade and allowing for recognition of a broader spectrum within an entity. Cribriform adenocarcinoma of (minor) salivary gland origin continues to be divisive in terms of whether it should be recognized as a distinct category. This chapter also features new key concepts such as high-grade transformation. The new paradigm of translocations and gene fusions being common in salivary gland tumors is featured heavily in this chapter.

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