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Phagocytosis following translocation of the neutrophil b-cytochrome from the specific granule to the plasma membrane is associated with an increased leakage of reactive oxygen species.

Artikel i vetenskaplig tidskrift
Författare H Lundqvist
Anna Karlsson
P Follin
C Sjölin
Claes Dahlgren
Publicerad i Scandinavian journal of immunology
Volym 36
Nummer/häfte 6
Sidor 885-91
ISSN 0300-9475
Publiceringsår 1992
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning
Institutionen för medicinsk mikrobiologi och immunologi
Sidor 885-91
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Cell Membrane, enzymology, Cytochrome b Group, physiology, Cytoplasmic Granules, enzymology, Humans, Hydrogen Peroxide, metabolism, Ionomycin, pharmacology, N-Formylmethionine Leucyl-Phenylalanine, pharmacology, Neutrophils, enzymology, metabolism, Phagocytosis, physiology, Respiratory Burst, drug effects, physiology
Ämneskategorier Immunologi inom det medicinska området

Sammanfattning

The effect of neutrophil b-cytochrome translocation on the respiratory burst activation generated during phagocytosis of yeast particles was investigated. Secretion of neutrophil specific granules was induced by the calcium ionophore ionomycin prior to phagocytosis. The secretory process is associated with a translocation from the specific granules to the plasma membrane of the respiratory burst b-cytochrome. Respiratory burst activity was measured as release of hydrogen peroxide in the absence of azide (extracellular leakage) and in the presence of azide (total production). The subcellular localization of the b-cytochrome was found to affect the extracellular release of hydrogen peroxide in that a plasma membrane localization was associated with a significantly increased release during phagocytosis. It should be pointed out, however, that most of the hydrogen peroxide, both in control and in ionomycin-treated cells, is produced intracellularly, probably in the phagosomes.

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