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Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes.

Artikel i vetenskaplig tidskrift
Författare Liz Rietschel
Fabian Streit
Gu Zhu
Kerrie McAloney
Josef Frank
Baptiste Couvy-Duchesne
Stephanie H Witt
Tina M Binz
John McGrath
Ian B Hickie
Narelle K Hansell
Margaret J Wright
Nathan A Gillespie
Andreas J Forstner
Thomas G Schulze
Stefan Wüst
Markus M Nöthen
Markus R Baumgartner
Brian R Walker
Andrew A Crawford
Lucía Colodro-Conde
Sarah E Medland
Nicholas G Martin
Marcella Rietschel
Claes Ohlsson
Dan Mellström
Publicerad i Scientific reports
Volym 7
Nummer/häfte 1
Sidor 15351
ISSN 2045-2322
Publiceringsår 2017
Publicerad vid Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 15351
Språk en
Länkar dx.doi.org/10.1038/s41598-017-11852...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Endokrinologi

Sammanfattning

Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.

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