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Adenosine mechanisms in the regulation of breathing in the rat.

Artikel i vetenskaplig tidskrift
Författare Per Wessberg
Jan A Hedner
Thomas Hedner
Bengt Persson
Jan Jonason
Publicerad i European journal of pharmacology
Volym 106
Nummer/häfte 1
Sidor 59-67
ISSN 0014-2999
Publiceringsår 1984
Publicerad vid Farmakologiska institutionen
Medicinska institutionen
Sidor 59-67
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adenosine, analogs & derivatives, pharmacology, Animals, Blood Gas Analysis, Blood Pressure, drug effects, Carbon Dioxide, pharmacology, Dose-Response Relationship, Drug, Heart Rate, drug effects, Male, Phenylisopropyladenosine, pharmacology, Rats, Rats, Inbred Strains, Receptors, Cell Surface, drug effects, Receptors, Purinergic, Respiration, drug effects, Respiratory Function Tests, Stereoisomerism, Theophylline, pharmacology, Xanthines, pharmacology
Ämneskategorier Farmakologi

Sammanfattning

The central respiratory effects of various adenosine (A) analogues were studied in halothane-anesthetized rats. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of the A analogues (2-Cla, L-PIA, CHA and NECA) reduced minute ventilation (VE) due to decreases in respiratory frequency (f) as well as tidal volume (VT). Dose-dependent effects were seen after i.c.v. L-PIA in both normal and vagotomized rats. Analysis of the A-induced changes using the occluded breath technique revealed an increase in expiratory time (TE) as well as a decrease in inspiratory drive. NECA, a relatively specific A2 agonist seemed to be somewhat more potent in eliciting respiratory depression than a relatively specific A1 agonist like L-PIA. Pretreatment with the methylxanthine theophylline completely antagonized the respiratory depression induced by L-PIA. It is concluded that central A receptors are involved in the central regulation of breathing and that A interacts with the respiratory control system mainly by decreasing inspiratory neural drive and prolonging expiratory time.

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