Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

An analysis of the mechan… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

An analysis of the mechanism by which gamma-aminobutyric acid depresses ventilation in the rat.

Artikel i vetenskaplig tidskrift
Författare Jan A Hedner
Thomas Hedner
Per Wessberg
Jan Jonason
Publicerad i Journal of applied physiology: respiratory, environmental and exercise physiology
Volym 56
Nummer/häfte 4
Sidor 849-56
ISSN 0161-7567
Publiceringsår 1984
Publicerad vid Farmakologiska institutionen
Sidor 849-56
Språk en
Länkar dx.doi.org/10.1152/jappl.1984.56.4....
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Aminooxyacetic Acid, pharmacology, Animals, Bicuculline, pharmacology, Biomechanical Phenomena, Blood Gas Analysis, Blood Pressure, drug effects, Brain, metabolism, Heart Rate, drug effects, Male, Medulla Oblongata, drug effects, Pons, drug effects, Rats, Rats, Inbred Strains, Respiration, drug effects, Tidal Volume, Time Factors, Tissue Distribution, gamma-Aminobutyric Acid, metabolism, physiology
Ämneskategorier Farmakologi

Sammanfattning

Intracerebroventricular administration of gamma-aminobutyric acid (GABA) or intraperitoneal injection of the GABA transaminase A inhibitor aminooxyacetic acid (AOAA) depressed ventilation in halothane-anesthetized rats. The depression was due to changes in both respiratory frequency (f) and tidal volume (VT) after GABA, whereas AOAA decreased only f. Intracerebroventricular GABA decreased inspiratory drive (VT/TI; intrapulmonary pressure at 100 ms) but did not change the bulbopontine setting of inspiratory duration (TI). Moreover, respiratory duty cycle (TI/TT) was decreased, and the ventilatory response to CO2 exposure was blunted. The ventilatory depression induced by GABA was reversed by the GABA antagonist bicuculline. The GABA content measured 45 min after AOAA administration was significantly increased in the whole brain, the hemispheres, striatum, and lower spinal cord regions. Whole-brain GABA content was significantly correlated to the changes in f, minute ventilation, TI, expiratory duration (TE), and total cycle duration. Furthermore, there was a significant negative correlation between brain stem GABA content and TI/TT but not VT/TI. In summary, GABA seems to interact with the central regulation of respiration at different levels in the brain. The main effect of increased endogenous concentrations of GABA is, however, a decrease in respiratory frequency due to a prolongation in TE.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?