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Sexual dimorphism of substrate utilization: Differences in skeletal muscle mitochondrial volume density and function

Artikel i vetenskaplig tidskrift
Författare D. Montero
Klavs Madsen
A. K. Meinild-Lundby
Fredrik Edin
Carsten Lundby
Publicerad i Experimental Physiology
Volym 103
Nummer/häfte 6
Sidor 851-859
ISSN 0958-0670
Publiceringsår 2018
Publicerad vid Institutionen för kost- och idrottsvetenskap
Sidor 851-859
Språk en
Länkar https://doi.org/10.1113/EP087007
Ämnesord body size, fat oxidation, mitochondria, sex differences, substrate metabolism, endurance exercise, gender-differences, fat oxidation, submaximal, exercise, enzyme-activity, oxygen-uptake, body-mass, women, men, metabolism, Physiology
Ämneskategorier Fysiologi

Sammanfattning

Fat oxidation during exercise is greater in females than in males. We sought to determine whether sex differences in substrate metabolism are paralleled by distinct skeletal muscle mitochondrial volume density and oxidative capacity. Whole-body substrate (fat and carbohydrate) utilization during submaximal treadmill running was assessed, and skeletal muscle biopsies were taken to determine mitochondrial volume density and function in healthy young females (n=12) and males (n=12) matched by aerobic exercise capacity and exercise performance. Females presented a lower respiratory exchange ratio (0.87 +/- 0.04 versus 0.91 +/- 0.04, P=0.023) and whole-body carbohydrate oxidation (27.8 +/- 8.3 versus 35.8 +/- 6.5mgkg(-1)min(-1), P=0.027), whereas fat oxidation was higher (8.7 +/- 2.8 versus 5.9 +/- 2.6mgkg(-1)min(-1), P=0.034) during submaximal exercise compared with males. In skeletal muscle biopsies, females demonstrated augmented mitochondrial volume density (7.51 +/- 1.77 versus 5.90 +/- 1.72%, P=0.035) and oxidative capacity for fatty acid [36.6 +/- 12.8 versus 24.5 +/- 7.3pmol O(2)s(-1)(mg wet weight)(-1), P=0.009] and lactate [71.1 +/- 24.4 versus 53.2 +/- 14.6pmol O(2)s(-1)(mg wet weight)(-1), P=0.040]. No sex differences in respiratory exchange ratio, whole-body fat oxidation and skeletal muscle variables were detected when adjusted for anthropometric variables including body mass or leg mass, which were lower in females. In conclusion, female prioritization of fat over carbohydrate oxidation during exercise is underpinned by augmented body size-related mitochondrial volume density, fatty acid and lactate oxidative capacity in skeletal muscle fibres.

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