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How to choose the suitable animal model of polycystic ovary syndrome?

Forskningsöversiktsartikel
Författare Amin Tamadon
Wei Hu
Peng Cui
Tong Ma
Xiaoyu Tong
Feifei Zhang
Xin Li
Linus Ruijin Shao
Yi Feng
Publicerad i Traditional Medicine and Modern Medicine
Volym 1
Nummer/häfte 2
Sidor 95-113
ISSN 2575-9000
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Sidor 95-113
Språk en
Länkar https://doi.org/10.1142/S2575900018...
https://www.researchgate.net/public...
Ämnesord Polycystic ovary syndrome animal model application
Ämneskategorier Fysiologi, Cell- och molekylärbiologi, Endokrinologi och diabetes, Reproduktionsmedicin och gynekologi

Sammanfattning

Polycystic ovary syndrome (PCOS) is a gynecological metabolic and endocrine disorder with uncertain etiology. To understand the etiology of PCOS or the evaluation of various therapeutic agents, different animal models have been introduced. Considering this fact that is difficult to develop an animal model that mimics all aspects of this syndrome, but, similarity of biological, anatomical, and/or biochemical features of animal model to the human PCOS phenotypes can increase its application. This review paper evaluates the recently researched animal models and introduced the best models for different research purposes in PCOS studies. During January 2013 to January 2017, 162 studies were identified which applied various kinds of animal models of PCOS including rodent, primate, ruminant and fish. Between these models, prenatal and pre-pubertal androgen rat models and then prenatal androgen mouse model have been studied in detail than others. The comparison of main features of these models with women PCOS demonstrates higher similarity of these three models to human conditions. Thereafter, letrozole models can be recommended for the investigation of various aspects of PCOS. Interestingly, similarity of PCOS features of post-pubertal insulin and human chorionic gonadotropin rat models with women PCOS were considerable which can make it as a good choice for future investigations.

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