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Variable increases of IgG and IgM antibodies in milk of IgA deficient women.

Artikel i vetenskaplig tidskrift
Författare M Hahn-Zoric
B Carlsson
Janne Björkander
Lotta Mellander
Vanda Friman
L Padyukov
Lars Åke Hanson
Publicerad i Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Volym 8
Nummer/häfte 3
Sidor 127-33
ISSN 0905-6157
Publiceringsår 1997
Publicerad vid Institutionen för kvinnors och barns hälsa
Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi
Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar
Institutionen för invärtesmedicin
Sidor 127-33
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Antibodies, Bacterial, isolation & purification, Antibodies, Viral, isolation & purification, Escherichia coli, immunology, Female, Humans, IgA Deficiency, immunology, Immunoblotting, Immunodiffusion, Immunoglobulin G, isolation & purification, Immunoglobulin M, isolation & purification, Immunosorbents, Isoelectric Focusing, Milk, Human, immunology, Poliovirus, immunology, Saliva, immunology
Ämneskategorier Infektionsmedicin

Sammanfattning

Serum, milk and saliva from seven IgA deficient mothers were studied for the presence of IgA, IgG and IgM antibodies to Escherichia coli and poliovirus antigens. Different variable patterns were obtained. One mother had very much increased IgM and IgG antibodies in milk and saliva against both antigens; the milk IgG antibodies were 11-14 times higher than the reference milk pool. Another mother showed also striking increases of both IgM and IgG antibodies in milk, as well as in saliva where the increases were much higher for the poliovirus than the E. coli antibodies. Yet another mother showed a certain increase of IgM but not of IgG antibodies in the milk. The uneven appearance of IgG and IgM antibodies in serum and secretions suggests local production. So do the differences of antibody avidities, the variations in IgG subclass distribution of antibodies and different patterns after isoelectric focusing (IEF)/immunoblotting analysis of antibody spectrotypes in secretions and serum. The study illustrates the variable patterns of compensatory increases of IgG and IgM antibodies which may occur in IgA deficiency. It also shows that the milk from IgA deficient mothers can still be rich in antibodies, in spite of the lack of secretory IgA.

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