Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Effect of sodium-potassiu… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Effect of sodium-potassium-dependent ATPase inhibition on noradrenaline-activated calcium sensitivity of mesenteric resistance vessels in adult spontaneously hypertensive rats.

Artikel i vetenskaplig tidskrift
Författare M J Mulvany
N Nyborg
Holger Nilsson
Publicerad i Clinical science (London, England : 1979)
Volym 59 Suppl 6
Sidor 203s-205s
ISSN 0143-5221
Publiceringsår 1980
Publicerad vid Fysiologiska institutionen
Sidor 203s-205s
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Calcium, pharmacology, Dose-Response Relationship, Drug, Female, Hypertension, physiopathology, In Vitro Techniques, Male, Mesenteric Arteries, drug effects, physiopathology, Muscle Contraction, drug effects, Muscle, Smooth, Vascular, drug effects, physiopathology, Norepinephrine, pharmacology, Ouabain, pharmacology, Rats, Sodium-Potassium-Exchanging ATPase, antagonists & inhibitors, metabolism
Ämneskategorier Fysiologi

Sammanfattning

1. We have investigated the noradrenaline-activated calcium sensitivity of 150 micrometer mesenteric resistance blood vessels from spontaneously hypertensive and control Wistar-Kyoto rats. 2. Under control conditions the spontaneously hypertensive rat blood vessels had a greater calcium sensitivity than the Wistar-Kyoto rat vessels. 3. In the presence of 1 mmol of ouabain/l, a treatment known to inhibit the sodium-potassium-dependent ATPase, the responses of the spontaneously hypertensive rat blood vessels were reduced more than those of the Wistar-Kyoto rat blood vessels, so that the responses of spontaneously hypertensive rat and Wistar-Kyoto rat blood vessels were then similar. 4. Similar results were obtained by removing external potassium, a procedure which should also inhibit the sodium-potassium-ATPase. 5. The results suggest that the greater noradrenaline-activated calcium sensitivity of spontaneously hypertensive rat blood vessels may be associated with an increased sodium-potassium-ATPase activity.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?