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| Författare |
Taija Heinosalo Niina Saarinen Matti Poutanen |
|---|---|
| Publicerad i | Molecular and cellular endocrinology |
| ISSN | 1872-8057 |
| Publiceringsår | 2018 |
| Publicerad vid |
Centre for Bone and Arthritis Research Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition |
| Språk | en |
| Länkar |
dx.doi.org/10.1016/j.mce.2018.08.00... www.ncbi.nlm.nih.gov/entrez/query.f... |
| Ämneskategorier | Endokrinologi |
Abnormal synthesis and metabolism of sex steroids is involved in the pathogenesis of various human diseases, such as endometriosis and cancers arising from the breast and uterus. Steroid biosynthesis is a multistep enzymatic process proceeding from cholesterol to highly active sex steroids via different intermediates. Human Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) enzyme shows a high capacity to produce the highly active estrogen, estradiol, from a precursor hormone, estrone. However, the enzyme may also play a role in other steps of the steroid biosynthesis pathway. In this article, we have reviewed the literature on HSD17B1, and summarize the role of the enzyme in hormone-dependent diseases in women as evidenced by preclinical studies.
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