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Development and in vivo response of hydroxyapatite/whitlockite from chicken bones as bone substitute using a chitosan membrane for guided bone regeneration

Artikel i vetenskaplig tidskrift
Författare J. H. Luna-Dominguez
H. Tellez-Jimenez
H. Hernandez-Cocoletzi
M. Garcia-Hernandez
J. A. Melo-Banda
Håkan Nygren
Publicerad i Ceramics International
Volym 44
Nummer/häfte 18
Sidor 22583-22591
ISSN 0272-8842
Publiceringsår 2018
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 22583-22591
Språk en
Länkar dx.doi.org/10.1016/j.ceramint.2018....
Ämnesord Guided bone regeneration, Whitlockite, Hydroxyapatite, Chitosan, Waste sources, composite scaffolds, porous membranes, tissue, whitlockite, particles, nanoparticles, combination, bioactivity, enamel, chitin
Ämneskategorier Biomaterialvetenskap

Sammanfattning

Biomaterials that meet the requirements to stimulate bone tissue formation play a vital role in orthopedics and dentistry. In this work, chitosan and a biphasic, non-cytotoxic material hydroxyapatite/whitlockite were obtained from natural sources, which are available as organic waste. The osteogenic activity was assessed using a rabbit model animal with a chitosan barrier membrane in combination with a bone-filling graft substitute composed of hydroxyapatite/whitlockite. FT-IR results showed the typical absorption bands of the chitosan and hydroxyapatite. Moreover, the X-ray diffraction pattern revealed a typical hexagonal phase of hydroxyapatite and rhombohedral structures related to whitlockite. Masson's trichrome stain showed an early formation of extracellular matrix mineralized, in accord with the surface morphology of a cortical mature bond observed by Scanning Electron Microscopy. The immunocytochemistry results showed a significant increase of positive immunoreactive cells to osteonectin in the treated defects in comparison with the control defects 6 and 8 weeks postoperatively. Overall, the results confirm that the use of this low-cost and versatile biomaterial as a barrier membrane and a bone substitute graft are useful for bone tissue engineering.

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