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The effect of pelvic nerve stimulation on recto-anal motility in the cat.

Artikel i vetenskaplig tidskrift
Författare S Buntzen
Leif Hultén
D Delbro
S Nordgren
Publicerad i Journal of the autonomic nervous system
Volym 61
Nummer/häfte 3
Sidor 243-7
ISSN 0165-1838
Publiceringsår 1996
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
Sidor 243-7
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adrenergic Antagonists, pharmacology, Anal Canal, innervation, physiology, Animals, Autonomic Nervous System, physiology, Cats, Electric Stimulation, Enzyme Inhibitors, pharmacology, Female, Male, Muscle Contraction, physiology, Nitric Oxide, biosynthesis, physiology, Nitric Oxide Synthase, antagonists & inhibitors, Peripheral Nerves, physiology, Rectum, innervation, physiology, Synaptic Transmission, physiology, omega-N-Methylarginine, pharmacology
Ämneskategorier Kirurgi

Sammanfattning

Rectal and anal motility responses to pharmacological manipulation of neuro-transmission and graded efferent electrical pelvic nerve stimulation were investigated in alpha-1-chloralose anaesthetized cats. N omega-nitro-L-arginine (L-NNA), a competitive inhibitor of nitric oxide synthase, did not influence spontaneous rectal and anal motility. No significant change in anal pressure or rectal tone was observed after sectioning the pelvic nerves in animals pretreated with L-NNA. The effect of pelvic nerve stimulation on anal tone was varying and depended upon the intensity of stimulation and the prevailing anal tone. A reduction of anal tone on pelvic nerve stimulation was consistently converted to an increase of anal tone after pretreatment with L-NNA. The rectal response to pelvic nerve stimulation was unchanged by L-NNA. Residual increase of anal tone observed on pelvic nerve stimulation after L-NNA and noradrenergic blockade was partly sensitive to hexamethonium and abolished by atropine. The results suggest that there is no tonic influence on rectal and anal motility via nitric oxide mechanisms. On the other hand, the reduction of anal tone on high intensity pelvic nerve stimulation seemed to be dependent on the release of nitric oxide. An excitatory cholinergic component of the smooth muscle contractility of the feline anal canal, partly sensitive to hexamethonium, was demonstrated to be conveyed in the pelvic nerves.

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