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| Författare |
Stefan Ebmeyer Erik Kristiansson D. G. Joakim Larsson |
|---|---|
| Publicerad i | The Journal of antimicrobial chemotherapy |
| Volym | 74 |
| Nummer/häfte | 5 |
| Sidor | 1202–1206 |
| ISSN | 1460-2091 |
| Publiceringsår | 2019 |
| Publicerad vid |
Institutionen för matematiska vetenskaper CARe - Centrum för antibiotikaresistensforskning Institutionen för biomedicin, avdelningen för infektionssjukdomar |
| Sidor | 1202–1206 |
| Språk | en |
| Länkar |
dx.doi.org/10.1093/jac/dkz025 www.ncbi.nlm.nih.gov/entrez/query.f... |
| Ämneskategorier | Mikrobiologi inom det medicinska området, Bioinformatik (beräkningsbiologi), Bioinformatik och systembiologi, Genetik |
To investigate the origin of CMY-1/MOX-family β-lactamases.Publicly available genome assemblies were screened for CMY-1/MOX genes. The loci of CMY-1/MOX genes were compared with respect to synteny and nucleotide identity, and subjected to phylogenetic analysis.The chromosomal ampC genes of several Aeromonas species were highly similar to known mobile CMY-1/MOX variants. Annotation and sequence comparison revealed nucleotide identities >98% and conserved syntenies between MOX-1-, MOX-2- and MOX-9-associated mobile sequences and the chromosomal Aeromonas sanarellii, Aeromonas caviae and Aeromonas media ampC loci. Furthermore, the phylogenetic analysis showed that MOX-1, MOX-2 and MOX-9 formed three distinct monophyletic groups with the chromosomal ampC genes of A. sanarellii, A. caviae and A. media, respectively.Our findings show that three CMY-1/MOX-family β-lactamases were mobilized independently from three Aeromonas species and hence shine new light on the evolution and emergence of mobile antibiotic resistance genes.
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