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EAACI Position Paper: Influence of Dietary Fatty Acids on Asthma, Food Allergy and Atopic Dermatitis.

Artikel i vetenskaplig tidskrift
Författare Carina Venter
Rosan W Meyer
Bright I Nwaru
Caroline Roduit
Eva Untersmayr
Karine Adel-Patient
Ioana Agache
Carlo Agostoni
Cezmi A Akdis
Stephan Bischoff
George du Toit
Mary Feeney
Remo Frei
Holger Garn
Matthew Greenhawt
Karin Hoffmann-Sommergruber
Nonhlanhla Lunjani
Kate Maslin
Clare Mills
Antonella Muraro
Isabella Pali
Lars Poulson
Imke Reese
Harald Renz
Graham C Roberts
Peter Smith
Sylwia Smolinska
Milena Sokolowska
Catherine Stanton
Berber Vlieg-Boerstra
Liam O'Mahony
Publicerad i Allergy
Volym 74
Nummer/häfte 8
Sidor 1429-44
ISSN 1398-9995
Publiceringsår 2019
Publicerad vid Krefting Research Centre
Sidor 1429-44
Språk en
Länkar dx.doi.org/10.1111/all.13764
Ämneskategorier Klinisk medicin, Hälsovetenskaper


The prevalence of allergic diseases such as allergic rhinitis, asthma, food allergy and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures and lifestyle practices. The purpose of this review is to highlight the potential role for dietary fatty acids, in the prevention and management of these disorders. In addition to their nutritive value, fatty acids have important immunoregulatory effects. Fatty acid-associated biological mechanisms, human epidemiology and intervention studies are summarized in this review. The influence of genetics and the microbiome on fatty acid metabolism is also discussed. Despite critical gaps in our current knowledge, it is increasingly apparent that dietary intake of fatty acids may influence the development of inflammatory and tolerogenic immune responses. However, the lack of standardized formats (i.e. food versus supplement), standardized doses and frequently a lack of pre-study serum fatty acid level assessments in clinical studies significantly limit our ability to compare allergy outcomes across studies and to provide clear recommendations at this time. Future studies must address these limitations and individualized medical approaches should consider the inclusion of specific dietary factors for the prevention and management of asthma, food allergy and atopic dermatitis. This article is protected by copyright. All rights reserved.

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