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Adherence of RFD-1 positive dendritic cells to the basal surface of thyroid follicular cells in Graves' disease.

Artikel i vetenskaplig tidskrift
Författare Johan Mölne
S Jansson
L E Ericson
M Nilsson
Publicerad i Autoimmunity
Volym 17
Nummer/häfte 1
Sidor 59-71
ISSN 0891-6934
Publiceringsår 1994
Publicerad vid Institutionen för laboratoriemedicin , Avdelningen för patologi
Sidor 59-71
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Antibodies, Monoclonal, immunology, Antigen-Presenting Cells, immunology, pathology, Autoimmune Diseases, immunology, pathology, Biomarkers, Cell Adhesion, Cell Differentiation, Cell Polarity, Dendritic Cells, pathology, Epithelium, immunology, pathology, Graves Disease, immunology, pathology, HLA-DR Antigens, analysis, Humans, Lymphocyte Subsets, immunology, pathology, Macrophages, immunology, pathology, Thyroid Gland, immunology, pathology
Ämneskategorier Patologi

Sammanfattning

HLA-DR positive cells infiltrating Graves' thyroid tissue were examined for their expression of cell-specific immunological markers using light and electron microscopic immunostaining of frozen sections and isolated open thyroid follicles. Graves' glands (n = 21) were enriched of CD68 and Leu-M5/CD11c positive monocytes/macrophages as well as CD4 and CD8 lymphocytes. These cell types were distributed juxta-follicular as well as in other tissue areas. Only the RFD-1 antibody, considered to label antigen-presenting cells including dendritic cells, identified cells invariably located close to the interstitial follicular surface. After follicle isolation, RFD-1 cells were enriched compared to Leu-M5 cells and exclusively adherent to the follicular epithelium. The plasma membrane of RFD-1 positive cells were in intimate contact with the basolateral membrane of the thyrocytes, sometimes extending deeply into the intercellular space of the epithelium. Parallel labelling experiments suggested that the follicle-adhering RFD-1 cells also expressed HLA-DR. Our findings show that in human thyroid glands with Graves' disease RFD-1 positive cells with a dendritic morphology establish direct contact with the follicular epithelium. In view of the fact that both HLA-DR and RFD-1 are associated with antigen-presenting functions it is suggested that a direct interaction of dendritic cells with thyrocytes might be an important component of the autoimmune reaction in Graves' disease.

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