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Non-polarized cell surface expression of HLA-A,B,C and HLA-DR antigens in Graves' thyroid follicle cells.

Artikel i vetenskaplig tidskrift
Författare Johan Mölne
M Nilsson
S Jansson
G Hansson
L E Ericson
Publicerad i Autoimmunity
Volym 10
Nummer/häfte 3
Sidor 189-99
ISSN 0891-6934
Publiceringsår 1991
Publicerad vid Institutionen för laboratoriemedicin , Avdelningen för patologi
Sidor 189-99
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Antigen-Presenting Cells, immunology, Cells, Cultured, Endothelium, Vascular, immunology, Female, Graves Disease, immunology, HLA-A Antigens, analysis, HLA-B Antigens, analysis, HLA-C Antigens, analysis, HLA-DR Antigens, analysis, Humans, Immunohistochemistry, Macrophages, immunology, Male, Middle Aged, Thyroid Gland, immunology
Ämneskategorier Morfologi

Sammanfattning

The intrathyroidal distribution and cell surface location of HLA-A,B,C and HLA-DR antigens was studied in polarized thyroid follicle cells from Graves' (n = 11) and normal (n = 3) thyroid tissue, using light and electron microscopy. Cryosections and isolated, open follicle segments were incubated with monoclonal antibodies against HLA-A,B,C and HLA-DR antigens and with patient sera containing autoantibodies against the microsomal antigen/thyroperoxidase. Immunoreactivity for HLA-A,B,C and HLA-DR on isolated thyroid follicle cells was frequently detected in Graves' disease, but absent in normal glands. There was a large variation in the immunolabelling between follicles as well as between different glands. Both HLA-A,B,C and HLA-DR immunoreactivity were detected on the apical and the basal surface of the follicle cells. Microsomal antigen/thyroperoxidase immunoreactivity was restricted to the apical cell surface. In contrast to normal tissue, HLA-DR positive cells with a dendritic or macrophage-like morphology were frequent in Graves' tissue. These cells adhered directly to the basal surface of isolated follicle segments. We conclude that HLA antigens are, unlike thyroid-specific plasma membrane constituents, expressed in a non-polarized manner at the surface of the follicular epithelium. These observations might have implications on the immune recognition of thyroidal autoantigens in Graves' disease.

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