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[Immunohistochemical study of P-cadherin in breast cancer].

Artikel i vetenskaplig tidskrift
Författare Anikó Kovács
Rosemary A Walker
András Nagy
Szabolcs Gomba
Louise Jones
Sheila Dearing
Publicerad i Orvosi hetilap
Volym 143
Nummer/häfte 8
Sidor 405-9
ISSN 0030-6002
Publiceringsår 2002
Publicerad vid Institutionen för laboratoriemedicin , Avdelningen för patologi
Sidor 405-9
Språk hun
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Breast Neoplasms, chemistry, pathology, Cadherins, analysis, Carcinoma, Ductal, Breast, chemistry, pathology, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Receptors, Estrogen, analysis, Receptors, Progesterone, analysis
Ämneskategorier Medicinsk laboratorievetenskap

Sammanfattning

Cell adhesion molecules play a significant role in the cellular connection of normal cells. The cadherins are believed to act as tumour suppressors, and their altered expression and function have been associated with tumour development.The authors examined the expression of a Ca++ dependent intercellular adhesion molecule, P-cadherin using an immunohistochemical method in 69 surgically resected breast carcinomas.P-cadherin was detected in 30 cases (43.5%, cytoplasmic and/or membrane staining). The expression of P-cadherin was independent of tumour size and lymph node status, but correlated with a high tumour grade (grade III). In contrast, expression of E-cadherin correlated with lower tumour grade (grade I-II). P-cadherin expression was not detected in invasive lobular carcinomas.In general, P-cadherin was expressed at a lower frequency compared to E-cadherin, alpha-, and beta-catenin. These results suggest that an inverse relationship may exist between E- and P-cadherin in relation to grade, and that the expression of P-cadherin may be a marker of aggressiveness.

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