Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Ephaptic interactions bet… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Ephaptic interactions between myelinated nerve fibres of rodent peripheral nerves

Artikel i vetenskaplig tidskrift
Författare Francesco Bolzoni
Elzbieta Jankowska
Publicerad i European Journal of Neuroscience
Volym 50
Nummer/häfte 7
Sidor 3101-3107
ISSN 0953-816X
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 3101-3107
Språk en
Länkar dx.doi.org/10.1111/ejn.14439
Ämnesord ephapse, myelinated nerve fibres, plasticity, rat, animal experiment, article, controlled study, dorsal root, gray matter, hindlimb, in vivo study, muscle spindle afferent nerve, myelinated nerve, nerve excitability, nonhuman, peripheral nerve, peroneus nerve, polarization, rodent, sciatic nerve, skin, sural nerve, tibial nerve
Ämneskategorier Neurovetenskaper

Sammanfattning

We report evidence that ephaptic interactions may occur between intact mammalian myelinated nerve fibres and not only between demyelinated or damaged mammalian nerve fibres or nerve cells as analysed in previous studies. The ephaptic interactions were investigated between nerve fibres traversing the lumbar dorsal roots and between bundles of fibres in the sciatic nerve in anaesthetized rats in vivo. The interactions were estimated by comparing the excitability of nerve fibres originating from one of the hindlimb nerves (peroneal or sural) under control conditions and when the stimulation of these fibres was combined with stimulation of another nerve (tibial). An increase in nerve volleys recorded from group I muscle afferents in the peroneal nerve and of the fastest skin afferents in the sural nerve was used as a measure of the increase in the excitability. The excitability of these fibres was increased during a fraction of a millisecond, coinciding with the period of passage of nerve impulses evoked by the conditioning stimulation of the tibial nerve. The degree of the increase was comparable to the increases in the excitability evoked by 1–2 min lasting fibre polarization. Ephaptic interactions were found to be more potent and with longer lasting after-effects within the dorsal roots than within the sciatic nerve. We postulate that ephaptic interactions may result in the synchronization of information forwarded via neighbouring afferent nerve fibres prior to their entry into the spinal cord and thereby securing the propagation of nerve impulses across branching points within the spinal grey matter. © 2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?