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Measurement of airway inflammation in current smokers by positron emission tomography

Artikel i vetenskaplig tidskrift
Författare S. Garpered
D. Minarik
S. Diaz
S. Valind
Lars Edenbrandt
P. Wollmer
Publicerad i Clinical Physiology and Functional Imaging
Volym 39
Nummer/häfte 6
Sidor 393-398
ISSN 1475-0961
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 393-398
Språk en
Länkar dx.doi.org/10.1111/cpf.12590
Ämnesord chronic obstructive pulmonary disease, computed tomography, lung density, positron emission tomography, pulmonary inflammation, lung, pet, density, burden, copd, Physiology
Ämneskategorier Diagnostisk radiologi

Sammanfattning

Background Accumulation of activated neutrophilic leucocytes is known to increase uptake of F-18-fluorodeoxyglucose (F-18-FDG) into lung tissue. Available evidence suggests that smokers and subjects with chronic obstructive pulmonary disease (COPD) have neutrophilic inflammation in peripheral airways. The aim of this study was to examine whether current smokers have higher lung tissue uptake of F-18-FDG than never-smokers when correcting for air fraction of the lungs. Methods We prospectively recruited 33 current smokers and 33 never-smokers among subjects referred for diagnosis or staging of cancer, other than lung cancer, with combined positron emission tomography/computed tomography (PET/CT) with F-18-FDG. Subjects with focal F-18-FDG uptake or focal CT abnormalities in the lungs were excluded. The lungs were segmented in the CT image, and lung density measured. F-18-FDG uptake was measured in the corresponding volume and corrected for air fraction. Results Lung uptake of F-18-FDG, corrected for air fraction, was 12 center dot 5 and 8 per cent higher in the right and left lungs, respectively, in current smokers than in never-smokers (P<0 center dot 05). Conclusion Abnormal lung tissue uptake of F-18-FDG may be masked by reduced lung density if the uptake is not related to air fraction. Increased uptake of F-18-FDG in lung tissue in current smokers relative to never-smokers may reflect inflammation in peripheral airways. Measurements of F-18-FDG uptake in the lung tissue may be useful for animal and human studies of airways disease in COPD and the relation between airway and systemic inflammation.

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