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Aseptic Ligatures Induce Marginal Peri-Implant Bone Loss-An 8-Week Trial in Rabbits.

Artikel i vetenskaplig tidskrift
Författare David Reinedahl
Silvia Galli
Tomas Albrektsson
Pentti Tengvall
Carina B. Johansson
Petra Hammarström Johansson
Ann Wennerberg
Publicerad i Journal of clinical medicine
Volym 8
Nummer/häfte 8
ISSN 2077-0383
Publiceringsår 2019
Publicerad vid Institutionen för odontologi
Institutionen för odontologi, sektion 2
Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Språk en
Länkar dx.doi.org/10.3390/jcm8081248
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord aseptic loosening; dental implant; ligature induced peri-implantitis; marginal bone loss; osseointegration
Ämneskategorier Biomaterialvetenskap, Biomaterial

Sammanfattning

The clinical value of ligature-induced experimental peri-implantitis studies has been questioned due to the artificial nature of the model. Despite repeated claims that ligatures of silk, cotton and other materials may not induce bone resorption by themselves; a recent review showed that the tissue reaction toward them has not been investigated. Hence, the current study aimed to explore the hard and soft tissue reactions toward commonly used ligature materials. A total of 60 dental implants were inserted into the femur (n = 20) and tibia (n = 40) of 10 rabbits. The femoral implants were ligated with sterile 3-0 braided silk in one leg and sterile cotton retraction chord in the other leg. The tibial implants were ligated with silk or left as non-ligated controls. All wounds were closed in layers. After a healing time of 8 weeks, femoral (silk versus cotton) and proximal tibial (silk versus non-ligated control) implants were investigated histologically. Distal tibial (silk versus non-ligated control) implants were investigated with real time polymerase chain reaction (qPCR). The distance from the implant-top to first bone contact point was longer for silk ligated implants compared to non-ligated controls (p = 0.007), but did not vary between cotton and silk. The ligatures triggered an immunological reaction with cell infiltrates in close contact with the ligature materials, adjacent soft tissue encapsulation and bone resorption. qPCR further demonstrated an upregulated immune response toward the silk ligatures compared to non-ligated controls. Silk and cotton ligatures provoke foreign body reactions of soft tissue encapsulation type and bone resorption around implants in the absence of plaque.

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