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Secular Trends in Pubertal Growth Acceleration in Swedish Boys Born from 1947 to 1996

Artikel i vetenskaplig tidskrift
Författare Claes Ohlsson
Maria Bygdell
Jimmy Celind
Arvid Sondén
A. Tidblad
L. Sävendahl
Jenny Kindblom
Publicerad i JAMA Pediatrics
Volym 173
Nummer/häfte 9
Sidor 860-865
ISSN 2168-6203
Publiceringsår 2019
Publicerad vid Core Facilities, Bioinformatics
Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 860-865
Språk en
Länkar dx.doi.org/10.1001/jamapediatrics.2...
Ämnesord article, body mass, child, childhood, cohort analysis, controlled study, growth acceleration, growth rate, height, human, human experiment, identity, linear regression analysis, major clinical study, male, puberty, retrospective study, school health service, Sweden, Swedish citizen
Ämneskategorier Pediatrik

Sammanfattning

Importance: A secular trend for earlier menarcheal age has been established in girls but there are few studies of pubertal timing for boys. Objective: To determine if there is a secular trend for earlier pubertal timing among boys. Design, Setting, and Participants: For this population-based retrospective cohort study conducted in Gothenburg, Sweden, we collected heights and weights from school health records for boys born consecutively from January 1 and onwards in 1947 and every 5 years from 1951 to 1996 (n = 375 for each birth cohort from 1947-1991, n = 340 for the birth cohort in 1996, and n = 4090 for the total cohort). We estimated age at the peak height velocity (PHV), the maximum growth velocity during puberty, and childhood body mass index (BMI) at age 8 years for all study participants. The data were analyzed during 2018 and 2019. Boys were eligible if they had a complete personal identity number and data to calculate their age at PHV and childhood BMI. Approximately 2.4% of the original study population was excluded because they lacked a personal identity number, and in the remaining study population, 4090 (69%) had sufficient data to calculate childhood BMI and age at PHV. Exposures: The exposure was birth year and a potential confounding factor was childhood BMI. Main Outcomes and Measures: The outcome was age at PHV. Results: Of the 4090 participants, most were white and the mean (SD) age at PHV was 13.9 (1.1) years. A linear regression model revealed a significant association between year of birth and age at PHV. Age at PHV was 1.5 months earlier for every decade increase in birth year (95% CI, -1.72 to -1.19; P <.001). After adjusting for childhood BMI, age at PHV was 1.2 months earlier per decade increase in birth year (95% CI, -1.41 to -0.89). All analyses were repeated in the subgroup of boys born in Sweden and with parents born in Sweden with similar results, indicating that the secular trend was not explained by demographic changes in the population between 1947 and 1996. Conclusions and Relevance: We provide evidence of a secular trend for earlier pubertal timing in boys that is partially explained by an increased childhood BMI, but other factors that are unknown contribute. © 2019 Ohlsson C et al.

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