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CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology

Artikel i vetenskaplig tidskrift
Författare J. S. Miners
P. G. Kehoe
S. Love
Henrik Zetterberg
Kaj Blennow
Publicerad i Alzheimers Research & Therapy
Volym 11
Nummer/häfte 1
ISSN 1758-9193
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Språk en
Länkar dx.doi.org/10.1186/s13195-019-0534-...
Ämnesord Platelet-derived growth factor receptor beta, PDGFR beta, Cerebrospinal fluid, CSF, CSF albumin, beta, degeneration, Neurosciences & Neurology
Ämneskategorier Neurovetenskaper

Sammanfattning

Background We aimed to assess the relationship between levels of a cerebrospinal fluid (CSF) marker of pericyte damage, soluble platelet-derived growth factor receptor beta (sPDGFR beta) and CSF markers of blood-brain barrier (BBB) integrity (CSF albumin and CSF/serum albumin ratio) and disease pathology (reduced CSF A beta 42 and elevated CSF total and phosphorylated tau) in Alzheimer's disease (AD). Methods sPDGFR beta and albumin were measured by sandwich ELISA in ante-mortem CSF from 39 AD and 39 age-matched controls that were grouped according to their biomarker profile (i.e. AD cases t-tau > 400 pg/mL, p-tau > 60 pg/mL and A beta 42 < 550 pg/mL). sPDGFR beta was also measured in matched serum and CSF samples (n = 23) in a separate neurologically normal group for which the CSF/serum albumin ratio had been determined. Results CSF sPDGFR beta level was significantly increased in AD (p = 0.0038) and correlated positively with albumin (r = 0.45, p = 0.007), total tau (r = 0.50, p = 0.0017) and phosphorylated tau (r = 0.41, p = 0.013) in AD but not in controls. CSF sPDGFR beta did not correlate with A beta 42. Serum and CSF sPDGFR beta were positively correlated (r = 0.547, p = 0.0085) in the independent neurologically normal CSF/serum matched samples. Conclusions We provide further evidence of an association between pericyte injury and BBB breakdown in AD and novel evidence that a CSF marker of pericyte injury is related to the severity of AD pathology.

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