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Evaluation of a sensor algorithm for motor state rating in Parkinson's disease

Artikel i vetenskaplig tidskrift
Författare Dongni Johansson
I. Thomas
A. Ericsson
A. Johansson
A. Medvedev
M. Memedi
D. Nyholm
F. Ohlsson
M. Senek
J. Spira
J. Westin
Filip Bergquist
Publicerad i Parkinsonism & Related Disorders
Volym 64
Nummer/häfte July
Sidor 112-117
ISSN 1353-8020
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 112-117
Språk en
Länkar dx.doi.org/10.1016/j.parkreldis.201...
Ämnesord Levodopa challenge test, Independent evaluation, Wearable sensors, Parkinson's disease, Machine, levodopa, fluctuations, reliability, dyskinesia, Neurosciences & Neurology
Ämneskategorier Neurologi

Sammanfattning

Introduction: A treatment response objective index (TRIS) was previously developed based on sensor data from pronation-supination tests. This study aimed to examine the performance of TRIS for medication effects in a new population sample with Parkinson's disease (PD) and its usefulness for constructing individual dose-response models. Methods: Twenty-five patients with PD performed a series of tasks throughout a levodopa challenge while wearing sensors. TRIS was used to determine motor changes in pronation-supination tests following a single levodopa dose, and was compared to clinical ratings including the Treatment Response Scale (TRS) and six sub-items of the UPDRS part III. Results: As expected, correlations between TRIS and clinical ratings were lower in the new population than in the initial study. TRIS was still significantly correlated to TRS (r(s) = 0.23, P < 0.001) with a root mean square error (RMSE) of 1.33. For the patients (n = 17) with a good levodopa response and clear motor fluctuations, a stronger correlation was found (r(s) = 0.38, RMSE = 1.29, P < 0.001). The mean TRIS increased significantly when patients went from the practically defined off to their best on state (P = 0.024). Individual dose-response models could be fitted for more participants when TRIS was used for modelling than when TRS ratings were used. Conclusion: The objective sensor index shows promise for constructing individual dose-response models, but further evaluations and retraining of the TRIS algorithm are desirable to improve its performance and to ensure its clinical effectiveness.

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