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Brown adipose tissue in human infants

Kapitel i bok
Författare Martin Lidell
Publicerad i Brown Adipose Tissue. Alexander Pfeifer, Martin Klingenspor, Stephan Herzig (red.). (Handbook of Experimental Pharmacology)
Sidor 107-123
ISBN 978-3-030-10512-9
Förlag Springer
Publiceringsår 2019
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 107-123
Språk en
Länkar dx.doi.org/10.1007/164_2018_118
Ämnesord Brown adipose tissue, Fetal, Human, Infant
Ämneskategorier Biokemi och molekylärbiologi, Cellbiologi

Sammanfattning

Adapting to the cold extrauterine environment after birth is a great challenge for the newborn. Due to their high surface area-to-volume ratio, infants tend to lose more heat to the environment as compared to adults. In addition, human newborns lack sufficiently developed skeletal muscle mass to maintain body temperature through shivering thermogenesis, an important source of heat in cold-exposed adults. Evolution has provided humans and other placental mammals with brown adipose tissue (BAT), a tissue that converts chemically stored energy, in the form of fatty acids and glucose, into heat through non-shivering thermogenesis. The thermogenic activity of this tissue is significant for the human infant’s ability to maintain a sufficiently high core body temperature. Although BAT has been studied in human infants for more than a century, the literature covering different aspects of the tissue is rather limited. The aim of this review is to summarize the literature and describe what is actually known about the tissue and its importance for early human life. © Springer International Publishing AG, part of Springer Nature 2018.

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