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Cerebrospinal fluid concentrations of extracellular matrix proteins in Alzheimer's disease

Artikel i vetenskaplig tidskrift
Författare Karolina Minta
Erik Portelius
S. Janelidze
O. Hansson
Henrik Zetterberg
Kaj Blennow
Ulf Andreasson
Publicerad i Journal of Alzheimer's Disease
Volym 69
Nummer/häfte 4
Sidor 1213-1220
ISSN 1387-2877
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 1213-1220
Språk en
Länkar dx.doi.org/10.3233/JAD-190187
Ämnesord Alzheimer's disease, Brevican, Neurocan, Tenascin-C, Tenascin-R
Ämneskategorier Neurovetenskaper

Sammanfattning

Background: Brevican, neurocan, tenascin-C, and tenascin-R are extracellular matrix (ECM) proteins that are mainly expressed in the brain. They play important roles in proliferation and migration of neurons and other cell types in the brain. These ECM proteins may also be involved in various pathologies, including reactive gliosis. Objective: The aim of the study was to investigate if ECM protein concentrations in cerebrospinal fluid (CSF) are linked to the neurodegenerative process in Alzheimer's disease (AD). Methods: Lumbar CSF samples from a non-AD control group (n = 50) and a clinically diagnosedADgroup (n = 42), matched for age and gender, were analyzed using commercially available ELISAs detecting ECM proteins. Mann-Whitney U test was used to examine group differences, while Spearman's rho test was used for correlations. Results: Brevican, neurocan, tenascin-R, and tenascin-C concentrations in AD patients did not differ compared to healthy controls or when the groups were dichotomized based on the Aβ42/40 cut-off. CSF tenascin-C and tenascin-R concentrations were significantly higher in women than in men in the AD group (p = 0.02). Conclusion: ECM proteins do not reflect AD-pathology in CSF. CSF tenascin-C and tenascin-R upregulation in women possibly reveal sexual dimorphism in the central nervous system immunity during AD. © 2019 - IOS Press and the authors. All rights reserved.

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