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C-reactive protein is more sensitive than erythrocyte sedimentation rate for diagnosis of infective endocarditis.

Artikel i vetenskaplig tidskrift
Författare Harriet Hogevik
Lars Olaison
Rune Andersson
Kjell Alestig
Publicerad i Infection
Volym 25
Nummer/häfte 2
Sidor 82-5
ISSN 0300-8126
Publiceringsår 1997
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar
Sidor 82-5
Språk en
Länkar dx.doi.org/10.1007/bf02113580
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Age Factors, Aged, Blood Sedimentation, C-Reactive Protein, analysis, metabolism, Endocarditis, Bacterial, diagnosis, Female, Hospitals, University, Humans, Lymphocyte Count, Male, Middle Aged, Platelet Count, Prospective Studies, Sensitivity and Specificity, Staphylococcal Infections, diagnosis, metabolism, Staphylococcus aureus, Streptococcal Infections, diagnosis, metabolism
Ämneskategorier Infektionsmedicin

Sammanfattning

The objective of this study was to evaluate the sensitivity of C-reactive protein (CRP) elevation compared to erythrocyte sedimentation rate (ESR), leucocyte count and thrombocyte count in the diagnosis of infective endocarditis (IE). It was designed as a prospective study of suspected episodes of IE in adults in tertiary care at a university-affiliated department of infectious diseases. In 89 episodes of IE, CRP was available from the start of treatment. Median age was 66 years, 45 were men and 44 women. Median CRP concentration was found to be 90 (range 0-357) mg/l with only 4% normal values. Episodes involving native valves had higher CRP than episodes occurring with prosthetic valves. Staphylococcal origin, short duration of symptoms, short duration of fever and highest recorded temperature all correlated to higher CRP levels. The CRP response was also prominent among patients > 70 years old. Among non-responders, a few cases with simultaneous cirrhosis were noted. ESR was less sensitive than CRP, with a normal level in 28% of the episodes. It was concluded that CRP determination is superior to erythrocyte sedimentation rate, leucocyte count and thrombocyte count in the diagnosis of infective endocarditis.

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