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UNALTERED LOW NERVE GROWTH FACTOR AND HIGH BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS IN PLASMA FROM PATIENTS WITH FIBROMYALGIA AFTER A 15-WEEK PROGRESSIVE RESISTANCE EXERCISE

Artikel i vetenskaplig tidskrift
Författare A. Jablochkova
E. Backryd
E. Kosek
Kaisa Mannerkorpi
M. Ernberg
B. Gerdle
B. Ghafouri
Publicerad i Journal of Rehabilitation Medicine
Volym 51
Nummer/häfte 10
Sidor 779-787
ISSN 1650-1977
Publiceringsår 2019
Publicerad vid Centrum för personcentrerad vård vid Göteborgs universitet (GPCC)
Institutionen för neurovetenskap och fysiologi
Sidor 779-787
Språk en
Länkar dx.doi.org/10.2340/16501977-2593
Ämnesord brain-derived neurotrophic factor, biomarker, chronic pain, fibromyalgia, nerve growth factor, plasma, cerebrospinal-fluid, central sensitization, central inflammation, chronic migraine, substance-p, pain, serum, bdnf, depression, neuropeptides, Rehabilitation, Sport Sciences
Ämneskategorier Neurologi

Sammanfattning

Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotro-phins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hyperalgesia. Few studies have examined circulating nerve growth factor and brain-derived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these peptides. Objectives: To compare plasma levels of nerve growth factor and brain-derived neurotrophic factor in fibromyalgia and in healthy controls, to investigate correlations between levels of nerve growth factor, brain-derived neurotrophic factor, and cytokines and clinical variables, and to investigate the effect of exercise on these levels. Subjects and methods: A total of 75 women with fibromyalgia participated in blood tests at baseline and after the 15-week intervention, and 25 healthy controls participated at baseline. Patients were randomized to a 15-week progressive resistance exercise intervention or a relaxation intervention. Results: Brain-derived neurotrophic factor level was significantly higher (p <0.001) and nerve growth factor level was significantly lower (p <0.001) in fibromyalgia than in healthy controls. Neither resistance exercise nor relaxation interventions affected the levels of brain-derived neurotrophic factor or nerve growth factor. No significant correlations were found between brain-derived neurotrophic factor or nerve growth factor plasma levels in fibromyalgia and cytokine levels or clinical variables. Conclusion: Changes in circulating nerve growth factor and brain-derived neurotrophic factor levels may affect nociception/pain in fibromyalgia. Clinical improvements were achieved following the exercise intervention, but the levels of brain-derived neurotrophic factor and nerve growth factor were not normalized.

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