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Towards elucidating the radiochemistry of astatine - Behavior in chloroform

Artikel i vetenskaplig tidskrift
Författare Emma Aneheim
Stig Palm
H. Jensen
C. Ekberg
Per Albertsson
Sture Lindegren
Publicerad i Scientific Reports
Volym 9
Sidor 9
ISSN 2045-2322
Publiceringsår 2019
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för radiofysik
Institutionen för kliniska vetenskaper, Avdelningen för onkologi
Sidor 9
Språk en
Länkar dx.doi.org/10.1038/s41598-019-52365...
Ämnesord alpha-particle radioimmunotherapy, radiopharmaceutical chemistry, targeted radiotherapeutics, at-211, dosimetry, extraction, stability, solvent, agents
Ämneskategorier Cancer och onkologi, Radiologi och bildbehandling

Sammanfattning

Targeted alpha therapy of disseminated cancer is an emerging technique where astatine-211 is one of the most promising candidate nuclides. Although astatine has been known for over 70 years, its chemistry is still largely unexplored, mainly due to the lack of stable or long-lived isotopes. However, substantial amounts of astatine-211 can be produced in cyclotrons by the bombardment of natural bismuth. The astatine can be recovered from the resulting irradiated target material through either wet extraction or dry-distillation. Chloroform has become an important intermediate solvent for the recovery of astatine after production, especially following dry distillation. In this work, the radiochemistry of astatine in chloroform was investigated using evaporation, solvent extraction, chromatographic methods and molecular modeling. The extraction of astatine in chloroform led to the formation of multiple astatine species, allowing for evaporation of the solvent to dryness without any loss of activity. Radiolysis products of chloroform were shown to play an important role in the speciation of astatine forming both reactive and kinetically stable compounds. It was hypothesized that reactions with chlorine, as well as trichloromethyl hydroperoxide, forming polar astatine compounds are important reactions under the current experimental conditions.

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