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Cohort profile: Thrombolysis in Ischemic Stroke Patients (TRISP): a multicentre research collaboration.

Artikel i vetenskaplig tidskrift
Författare Jan F Scheitz
Henrik Gensicke
Sanne M Zinkstok
Sami Curtze
Marcel Arnold
Christian Hametner
Alessandro Pezzini
Guillaume Turc
Andrea Zini
Visnja Padjen
Susanne Wegener
Annika Nordanstig
Lars Kellert
Georg Kägi
Yannick Bejot
Patrik Michel
Didier Leys
Christian H Nolte
Paul J Nederkoorn
Stefan T Engelter
Katarina Jood
Publicerad i BMJ open
Volym 8
Nummer/häfte 9
Sidor e023265
ISSN 2044-6055
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor e023265
Språk en
Länkar dx.doi.org/10.1136/bmjopen-2018-023...
Ämnesord Administration, Intravenous, Brain Ischemia, complications, therapy, Endovascular Procedures, adverse effects, Fibrinolytic Agents, adverse effects, therapeutic use, Humans, Intersectoral Collaboration, Prospective Studies, Registries, Stroke, etiology, therapy, Thrombectomy, adverse effects
Ämneskategorier Neurologi


The ThRombolysis in Ischemic Stroke Patients (TRISP) collaboration aims to address clinically relevant questions about safety and outcomes of intravenous thrombolysis (IVT) and endovascular thrombectomy. The findings can provide observational information on treatment of patients derived from everyday clinical practice.TRISP is an open, investigator-driven collaborative research initiative of European stroke centres with expertise in treatment with revascularisation therapies and maintenance of hospital-based registries. All participating centres made a commitment to prospectively collect data on consecutive patients with stroke treated with IVT using standardised definitions of variables and outcomes, to assure accuracy and completeness of the data and to adapt their local databases to answer novel research questions.Currently, TRISP comprises 18 centres and registers >10 000 IVT-treated patients. Prior TRISP projects provided evidence on the safety and functional outcome in relevant subgroups of patients who were excluded, under-represented or not specifically addressed in randomised controlled trials (ie, pre-existing disability, cervical artery dissections, stroke mimics, prior statin use), demonstrated deficits in organisation of acute stroke care (ie, IVT during non-working hours, effects of onset-to-door time on onset-to-needle time), evaluated the association between laboratory findings on outcome after IVT and served to develop risk estimation tools for prediction of haemorrhagic complications and functional outcome after IVT.Further TRISP projects to increase knowledge of the effect and safety of revascularisation therapies in acute stroke are ongoing. TRISP welcomes participation and project proposals of further centres fulfilling the outlined requirements. In the future, TRISP will be extended to include patients undergoing endovascular thrombectomy.

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