Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Radiation-induced dysphag… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Radiation-induced dysphagia in head and neck cancer - risk structures and methodological aspects

Doktorsavhandling
Författare Johanna Hedström
Datum för examination 2019-09-20
ISBN 978-91-7833-491-9
Förlag Göteborgs universitet
Publiceringsår 2019
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar
Språk en
Länkar hdl.handle.net/2077/59058
Ämnesord head and neck cancer, radiation therapy, dysphagia, patient-reported outcomes, quality of care
Ämneskategorier Radiologi, Oto-rino-laryngologi, Cancer och onkologi

Sammanfattning

Background/Aims: Swallowing difficulties are common after radiation therapy (RT) in head and neck cancer (HNC). The overall aim of this thesis was to address radiation-induced late dysphagia with regard to investigating anatomical risk structures related to the development of radiation-induced dysphagia, as well as methodological aspects in the evaluation of swallowing. Another objective was to translate and validate the quality of care instrument Swallowing Quality of Care questionnaire (SWAL-CARE) in a mixed Swedish dysphagia population. Methods: The studies were conducted at the Sahlgenska University Hospital and included patients from the otorhinolaryngology clinic. In study I-III, patients who had received curative (chemo)RT for HNC underwent a videofluoroscopic examination of swallowing function (VFS) 6-36 months post-RT. Dysphagia severity was measured according to the Penetration-Aspiration Scale (PAS). All patients answered questions regarding difficulties when drinking, eating, swallowing and coughing when eating/drinking (DESdC). Study I included 38 patients, and the VFS protocol included six boluses of different consistencies and sizes and two swallowing attempts per bolus. Comparisons were made regarding differences in PAS score between the first and second swallowing attempt for the respective boluses. Study II included 118 patients, and associations between DESdC and PAS scores were determined. Study III included 90 patients with delineation of potential risk structures for radiation-induced dysphagia. Associations between radiation dose and dysphagia severity were evaluated and relevant dose predictors were identified. In Study IV, translation and validation of the SWAL-CARE was performed. Field testing was conducted including 100 patients with oropharyngeal dysphagia. Results: In Study I, no differences were found between the first and second swallow attempt in VFS regarding PAS score, however large intra-individual dispersion was found. In Study II, a discrepancy regarding the severity of self-reported swallowing difficulties and instrumentally measured dysphagia was found. However, half of the patients who reported occurrence of at least three dysphagia symptoms (DESdC) also demonstrated high PAS score (≥6). In Study III, the mean dose to the epiglottis had the best discriminative ability for severe dysphagia (PAS≥6). Doses to the larynx and the contralateral submandibular gland as well as the parotid gland were also of importance. In Study IV, the validation of the S-SWAL-CARE demonstrated high validity and good internal consistency. Conclusion: In order to test the swallowing safety, the highest PAS score should be reported in VFS. Furthermore, if a patient reports difficulties eating, drinking and swallowing when asked direct questions it is likely that the patient will present with moderate to severe dysphagia according to PAS. In addition to established dysphagia organs-at-risk (OARs), our data suggest that epiglottic and submandibular gland doses are important for swallowing function post-RT. Finally, the S-SWAL-CARE can be considered a reliable and valid tool to assess the dysphagia-related quality of care. Keywords: head and neck neoplasms; radiation therapy; dysphagia; videofluoroscopy; Penetration-Aspiration Scale (PAS); patient-reported outcomes (PRO); Quality of Care; validation studies

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?