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Education modulates brain maintenance in presymptomatic frontotemporal dementia.

Artikel i vetenskaplig tidskrift
Författare Stefano Gazzina
Mario Grassi
Enrico Premi
Maura Cosseddu
Antonella Alberici
Silvana Archetti
Roberto Gasparotti
John Van Swieten
Daniela Galimberti
Raquel Sanchez-Valle
Robert Jr Laforce
Fermin Moreno
Matthis Synofzik
Caroline Graff
Mario Masellis
Maria Carmela Tartaglia
James B Rowe
Rik Vandenberghe
Elizabeth Finger
Fabrizio Tagliavini
Alexandre de Mendonça
Isabel Santana
Christopher R Butler
Simon Ducharme
Alex Gerhard
Adrian Danek
Johannes Levin
Markus Otto
Giovanni Frisoni
Sandro Sorbi
Alessandro Padovani
Jonathan D Rohrer
Barbara Borroni
Henrik Zetterberg
Publicerad i Journal of neurology, neurosurgery, and psychiatry
Volym 90
Nummer/häfte 10
Sidor 1124-1130
ISSN 1468-330X
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 1124-1130
Språk en
Länkar dx.doi.org/10.1136/jnnp-2019-320439
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Neurokemi

Sammanfattning

Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time.Two-hundred twenty-nine subjects at-risk of carrying a pathogenic mutation leading to FTD underwent longitudinal cognitive assessment and T1-weighted MRI at baseline and at 1 year follow-up. The first principal component score of the graph-Laplacian Principal Component Analysis on 112 grey matter region-of-interest volumes was used to summarise the grey matter volume (GMV). The effects of education on cognitive performances and GMV at baseline and on the change between 1 year follow-up and baseline (slope) were tested by Structural Equation Modelling.Highly educated at-risk subjects had better cognition and higher grey matter volume at baseline; moreover, higher educational attainment was associated with slower loss of grey matter over time in mutation carriers.This longitudinal study demonstrates that even in presence of ongoing pathological processes, education may facilitate both brain reserve and brain maintenance in the presymptomatic phase of genetic FTD.

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