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High intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): a multicentre randomised trial of 100 patients.

Artikel i vetenskaplig tidskrift
Författare Silje Halvorsen Sveaas
Annelie Bilberg
Inger Jorid Berg
Sella Arrestad Provan
Silvia Rollefstad
Anne Grete Semb
Kåre Birger Hagen
Melissa Woll Johansen
Elisabeth Pedersen
Hanne Dagfinrud
Publicerad i British journal of sports medicine
ISSN 1473-0480
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering
Språk en
Länkar dx.doi.org/10.1136/bjsports-2018-09...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Sjukgymnastik

Sammanfattning

Exercise is considered important in the management of patients with rheumatic diseases, but the effect of high intensity exercises on disease activity is unknown.To investigate the effectiveness of high intensity exercises on disease activity in patients with axial spondyloarthritis (axSpA).Assessor blinded multicentre randomised controlled trial. 100 patients (aged from their 20s to their 60s) with axSpA were randomly assigned to an exercise group or to a no-intervention control group. The exercise group performed cardiorespiratory and muscular strength exercises at high intensity over 3 months. The control group received standard care and was instructed to maintain their usual physical activity level. Primary outcome was disease activity measured with the Ankylosing Spondylitis (AS) Disease Activity Scale (ASDAS, higher score=worst) and the Bath AS Disease Activity Index (BASDAI, 0-10, 10=worst). Secondary outcomes were inflammatory markers, physical function and cardiovascular (CV)-health. There was patient involvement in the design and reporting of this study.97 of the 100 (97%) randomised patients completed the measurements after the intervention. There was a significant treatment effect of the intervention on the primary outcome (ASDAS: -0.6 [-0.8 to -0.3], p<0.001 and BASDAI: -1.2 [-1.8 to -0.7], p<0.001). Significant treatment effects were also seen for inflammation, physical function and CV-health.High intensity exercises reduced disease symptoms (pain, fatigue, stiffness) and also inflammation in patients with axSpA. It improves patients' function and CV health. This debunks concerns that high intensity exercise might exacerbate disease activity in patients with axSpA.NCT02356874.

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