Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Being overweight in child… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?

Artikel i vetenskaplig tidskrift
Författare A. Johannessen
M. Lønnebotn
L. Calciano
B. Benediktsdóttir
R. J. Bertelsen
L. Bråbäck
S. Dharmage
K. A. Franklin
T. Gislason
M. Holm
C. Janson
D. Jarvis
R. Jõgi
Jeong-Lim Kim
J. Kirkeleit
C. Lodge
A. Malinovschi
J. Martinez-Moratalla
R. M. Nilsen
A. Pereira-Vega
F. G. Real
V. Schlünssen
S. Accordini
C. Svanes
Publicerad i Journal of Allergy and Clinical Immunology
ISSN 0091-6749
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin
Språk en
Länkar dx.doi.org/10.1016/j.jaci.2019.08.0...
Ämnesord Ageing Lungs in European Cohorts study, epidemiology, multilevel mediation model, offspring, parental risk factors
Ämneskategorier Allergologi, Epidemiologi

Sammanfattning

Background: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. Objective: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. Methods: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. Results: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. Conclusion: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health. © 2019 The Authors

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?