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IL-1beta, IL-6, TNFalpha, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis.

Artikel i vetenskaplig tidskrift
Författare Inger Mattsby-Baltzer
Jens Jörgen Platz-Christensen
Nosrat Hosseini Johnsson
Petra Rosén
Publicerad i Acta obstetricia et gynecologica Scandinavica
Volym 77
Nummer/häfte 7
Sidor 701-6
ISSN 0001-6349
Publiceringsår 1998
Publicerad vid Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi
Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi
Sidor 701-6
Språk en
Länkar https://doi.org/10.1034/j.1600-0412...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Bacteroidaceae Infections, immunology, metabolism, microbiology, Cervix Mucus, metabolism, Endotoxins, metabolism, Female, Fibronectins, metabolism, Genitalia, Female, immunology, metabolism, microbiology, Humans, Interleukin-1, metabolism, Interleukin-6, metabolism, Pregnancy, Pregnancy Complications, Infectious, immunology, metabolism, microbiology, Pregnancy Trimester, First, Prevotella, Tumor Necrosis Factor-alpha, metabolism, Vaginosis, Bacterial, immunology, metabolism, microbiology
Ämneskategorier Reproduktionsmedicin och gynekologi, Bakteriologi, Immunologi

Sammanfattning

In our studies on women with bacterial vaginosis (BV) in early pregnancy a strong association has been found between BV and the levels of endotoxin or interleukin-1alpha (IL-1alpha) in the lower genital tract. In the present study we investigated if an association could be found between BV and other cytokines (IL-1beta, IL-6, tumor necrosis factor alpha, TNF) or fetal fibronectin (FFN). The cytokine-inducing capacity of endotoxins present in the cervical mucus was explored in a monocytic cell assay.Cervical mucus or cervicovaginal fluid was collected from women with (BV) and without BV (nonBV) attending a family planning unit for first trimester abortion. The concentrations of IL-1beta, IL-6, TNF and FFN were determined by quantitative enzyme immunoassays. TNF was determined in 63 women (BV, n=25) out of whom 37 (BV, n=11) were analyzed for IL-1beta and the remaining 26 for IL-6 (BV, n=14). FFN was determined in another 36 women (BV, n= 19). The cytokine-inducing capacity of endotoxin-containing cervical mucus and purified endotoxin of Prevotella bivia were studied by an in vitro cell assay using a human monocytic cell line (THP-1).IL-lbeta and IL-6 were found in almost all women. The levels of IL-1beta, but not IL-6, TNF or FFN, were significantly increased in women with BV compared with the nonBV women (p<0.05). Purified endotoxin from P. bivia, and cervical mucus from BV women containing high levels of endotoxin were able to induce a cytokine response (IL-6) in monocytic cells in vitro.BV is associated with increased levels of IL-1beta in the lower genital tract of pregnant women in the first trimester. The ability of BV-associated endotoxins to induce cytokine production in monocytic cells may partly explain the increased IL-1beta levels.

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