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Beta-Cell Function, Self-rated Health, and Lifestyle Habits in 64-Year-Old Swedish Women with Metabolically Healthy Obesity Phenotype

Artikel i vetenskaplig tidskrift
Författare Ola Hjelmgren
Anders Gummesson
Göran Bergström
Caroline Schmidt
Publicerad i Journal of Obesity & Metabolic Syndrome
Volym 29
Nummer/häfte 1
Sidor 39-46
ISSN 2508-6235
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 39-46
Språk en
Länkar dx.doi.org/10.7570/jomes19078
Ämnesord Metabolically benign obesity, Health, Life style, impaired glucose-tolerance, risk, inflammation, mortality, Endocrinology & Metabolism
Ämneskategorier Endokrinologi och diabetes

Sammanfattning

Background: A subset of obese individuals do not present metabolic abnormalities that commonly define the metabolic syndrome (MetS). This is referred to as a metabolically healthy obese (MHO) phenotype. The aim of the present study was to evaluate the prevalence of the MHO phenotype and its relationship with beta cell dysfunction by measuring C-peptide and proinsulin, anthropometric-, metabolic- and lipid appearance, as well as lifestyle behaviors and self-rated health in a cohort of 64-year-old Swedish women. Methods: The National Cholesterol Education Program definition was used to assess MetS. We defined normal weight as body mass index (BMI) 18.5-24.9 kg/m(2) and obesity as BMI >= 30 kg/m(2) to categorize participants as metabolically healthy normal weight, MHO, and metabolically unhealthy obese. Results: The MHO phenotype represented 36.3% of obese participants and 16.3% of total participants. The MHO group were at greater risk of having proinsulin levels >11 pmol/L, indicating impaired beta cell function. Further, homeostatic model assessment for insulin resistance, fasting plasma levels of insulin, and C-peptide showed significant trends, with the MHO phenotype group having intermediate levels among three groups. Health behaviors such as leisure time physical activity and alcohol intake were also intermediate in individuals with the MHO phenotype. Conclusion: In this study, we demonstrate that over a third of the obese women in our sample were MHO. Further, women with the MHO phenotype showed intermediate profiles considering beta cell function and insulin resistance, as well as metabolic variables, and tended to rate their general health as worse than otherwise similar individuals of normal weight.

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