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Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Artikel i vetenskaplig tidskrift
Författare A. K. Heath
D. C. Muller
P. A. van den Brandt
N. Papadimitriou
E. Critselis
M. Gunter
P. Vineis
E. Weiderpass
G. Fagherazzi
H. Boeing
P. Ferrari
A. Olsen
A. Tjonneland
P. Arveux
M. C. Boutron-Ruault
F. R. Mancini
T. Kuhn
R. Turzanski-Fortner
M. B. Schulze
A. Karakatsani
P. Thriskos
A. Trichopoulou
G. Masala
P. Contiero
F. Ricceri
S. Panico
B. Bueno-de-Mesquita
M. F. Bakker
C. H. van Gils
K. S. Olsen
G. Skeie
C. Lasheras
A. Agudo
M. Rodriguez-Barranco
M. J. Sanchez
P. Amiano
M. D. Chirlaque
A. Barricarte
I. Drake
U. Ericson
I. Johansson
Anna Winkvist
T. Key
H. Freisling
M. His
I. Huybrechts
S. Christakoudi
M. Ellingjord-Dale
E. Riboli
K. K. Tsilidis
I. Tzoulaki
Publicerad i Breast Cancer Research
Volym 22
Nummer/häfte 1
Sidor 12
ISSN 1465-5411
Publiceringsår 2020
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 12
Språk en
Länkar dx.doi.org/10.1186/s13058-019-1244-...
Ämnesord Breast cancer, Diet, Foods, Nutrients, Alcohol, Fibre, dietary fiber intake, serum estrogen concentrations, scale prospective, cohort, postmenopausal women, pooled analysis, alcohol, nutrition, premenopausal, questionnaire, metaanalysis, Oncology
Ämneskategorier Cancer och onkologi

Sammanfattning

Background Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. Methods Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). Results Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. Conclusions Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.

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