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Relevance of biomarkers across different neurodegenerative.

Forskningsöversiktsartikel
Författare Alexander J Ehrenberg
Ayesha Khatun
Emma Coomans
Matthew J Betts
Federica Capraro
Elisabeth H Thijssen
Konstantin Senkevich
Tehmina Bharucha
Mehrsa Jafarpour
Peter N E Young
William Jagust
Stephen F Carter
Tammaryn Lashley
Lea T Grinberg
Joana B Pereira
Niklas Mattsson-Carlgren
Nicholas J Ashton
Jörg Hanrieder
Henrik Zetterberg
Michael Schöll
Ross W Paterson
Publicerad i Alzheimer's research & therapy
Volym 12
Nummer/häfte 1
Sidor 56
ISSN 1758-9193
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Wallenberg Centre for Molecular and Translational Medicine
Sidor 56
Språk en
Länkar dx.doi.org/10.1186/s13195-020-00601...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Biomedicinsk laboratorievetenskap/teknologi, Neurovetenskaper

Sammanfattning

The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and increasing use, appropriate implementation and interpretation are paramount. Various biomarkers feature nuanced differences in strengths, limitations, and biases that must be considered when investigating disease etiology and clinical utility. For example, neuropathological investigations of Alzheimer's disease pathogenesis can fall in disagreement with conclusions reached by biomarker-based investigations. Considering the varied strengths, limitations, and biases of different research methodologies and approaches may help harmonize disciplines within the neurodegenerative disease field.Along with separate review articles covering fluid and imaging biomarkers in this issue of Alzheimer's Research and Therapy, we present the result of a discussion from the 2019 Biomarkers in Neurodegenerative Diseases course at the University College London. Here, we discuss themes of biomarker use in neurodegenerative disease research, commenting on appropriate use, interpretation, and considerations for implementation across different neurodegenerative diseases. We also draw attention to areas where biomarker use can be combined with other disciplines to understand issues of pathophysiology and etiology underlying dementia. Lastly, we highlight novel modalities that have been proposed in the landscape of neurodegenerative disease research and care.

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